Does early cystectomy improve survival of patients with high-risk superficial bladder tumors? Journal Article
| Authors: | Herr, H. W.; Sogani, P. C. |
| Article Title: | Does early cystectomy improve survival of patients with high-risk superficial bladder tumors? |
| Abstract: | Purpose: Comparison of survival after early and delayed cystectomy in patients with high risk superficial bladder tumors. Patients and Methods: Of 307 patients with high risk superficial bladder tumors treated initially with transurethral resection and BCG-therapy, 90 (29%) underwent a cystectomy for recurrent tumor during a follow-up period of 15 to 20 years. Disease-specific survival distribution of these 90 patients was determined relativ to the indications for and time of cystectomy. Results: A total of 44 (49%) of the 90 cystectomized patients survived for a median time of 96 months. Of 35 patients with recurrent superficial bladder tumors initially treated with BCG, 92% of those cystectomized within 2 years after BCG-therapy survived as compared to 56% who had undergone cystectomy after 2 years of follow-up. Of 55 patients with recurrent muscle-invasive bladder tumors, 41% survived when cystectomy was performed within 2 years compared to 18% after 2 years. A multivariate analysis showed that early cystectomy improved survival in patients with non-muscle-invasive tumor relapse. Conclusion: Earlier cystectomy improves the long-term survival of patients with high risk superficial bladder tumors who fail BCG-therapy. |
| Keywords: | radical cystectomy; progression; bacillus-calmette-guerin; ta; cancer; tis |
| Journal Title: | Aktuelle Urologie |
| Volume: | 32 |
| Issue: | 6 |
| ISSN: | 0001-7868 |
| Publisher: | Georg Thieme Verlag Kg |
| Date Published: | 2001-10-01 |
| Start Page: | 360 |
| End Page: | 363 |
| Language: | German |
| ACCESSION: | WOS:000172305500002 |
| DOI: | 10.1055/s-2001-18297 |
| PROVIDER: | wos |
| Notes: | Article -- Source: Wos |
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