Does early cystectomy improve the survival of patients with high risk superficial bladder tumors? Journal Article


Authors: Herr, H. W.; Sogani, P. C.
Article Title: Does early cystectomy improve the survival of patients with high risk superficial bladder tumors?
Abstract: Purpose: We compared survival after early versus delayed cystectomy in patients with high risk superficial bladder tumors. Materials and Methods: Of 307 patients with high risk superficial bladder tumors who were treated initially with transurethral resection and bacillus Calmette-Guerin (BCG) therapy 90 (29%) underwent cystectomy for recurrent tumor during a followup of 15 to 20 years. Disease specific survival distribution of these 90 patients was determined relative to the indications for and time of cystectomy. Results: Of the 90 patients who underwent cystectomy 44 (49%) survived a median of 96 months. Of 35 patients with recurrent superficial bladder tumors 92% and 56% survived who underwent cystectomy less than 2 years after initial BCG therapy and after 2 years of followup, respectively. Of 55 patients with recurrent muscle invasive bladder disease 41% and 18% survived when cystectomy was performed within and after 2 years, respectively. Multivariate analysis showed that survival was improved in patients who underwent earlier rather than delayed cystectomy for nonmuscle invasive tumor relapse. Conclusions: Earlier cystectomy improves the long-term survival of patients with high risk superficial bladder tumors in whom BCG therapy fails.
Keywords: adult; cancer survival; aged; middle aged; survival rate; major clinical study; follow up; follow-up studies; neoplasm staging; treatment indication; bcg vaccine; neoplasm recurrence, local; risk factors; bladder tumor; urinary bladder neoplasms; high risk patient; time factors; risk; survival time; tumor recurrence; cystectomy; mycobacterium bovis; multivariate analysis; bladder neoplasms; transurethral resection; adjuvants, immunologic; bladder; superficial cancer; humans; prognosis; human; male; female; priority journal; article
Journal Title: Journal of Urology
Volume: 166
Issue: 4
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 2001-10-01
Start Page: 1296
End Page: 1299
Language: English
PUBMED: 11547061
PROVIDER: scopus
DOI: 10.1016/S0022-5347(05)65756-4
DOI/URL:
Notes: Export Date: 21 May 2015 -- Source: Scopus
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  1. Pramod C Sogani
    75 Sogani
  2. Harry W Herr
    594 Herr