Defining bacillus Calmette-Guerin refractory superficial bladder tumors Journal Article
| Authors: | Herr, H. W.; Dalbagni, G. |
| Article Title: | Defining bacillus Calmette-Guerin refractory superficial bladder tumors |
| Abstract: | Purpose: We define bacillus Calmette-Guerin (BCG) refractory, high risk, superficial bladder cancer. Materials and Methods: A total of 93 patients received a 6-week induction course of BCG. They were evaluated for response after 3 and 6 months. Half of the patients received monthly maintenance BCG for 2 years and half did not. In both groups the initial responses to BCG at 3 and 6 months were correlated with subsequent tumor recurrence and progression. Results: Of the 93 cases 57% were negative for tumor at 3 months and 43% had residual tumor resected. At 6 months 80% of the patients were tumor-free and 20% had persistent or recurrent tumor. Maintenance BCG did not decrease tumor recurrence further than induction BCG. Subsequent tumor-free interval during 24 months of followup were best predicted by response to BCG after 6 months. Conclusions: A minimum treatment and followup time of 6 months is required to identify high risk, superficial bladder tumors as truly BCG refractory. |
| Keywords: | treatment outcome; treatment failure; major clinical study; cancer recurrence; salvage therapy; cancer growth; cancer risk; follow up; bcg vaccine; drug resistance; drug resistance, neoplasm; bladder cancer; bladder tumor; urinary bladder neoplasms; time factors; disease progression; bladder neoplasms; adjuvants, immunologic; humans; human; priority journal; article |
| Journal Title: | Journal of Urology |
| Volume: | 169 |
| Issue: | 5 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2003-05-01 |
| Start Page: | 1706 |
| End Page: | 1708 |
| Language: | English |
| DOI: | 10.1097/01.ju.0000062605.92268.c6 |
| PUBMED: | 12686813 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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