Bacillus calmette-guérin without maintenance therapy for high-risk non-muscle-invasive bladder cancer Journal Article
| Authors: | Herr, H. W.; Dalbagni, G.; Donat, S. M. |
| Article Title: | Bacillus calmette-guérin without maintenance therapy for high-risk non-muscle-invasive bladder cancer |
| Abstract: | Background: Bacillus Calmette-Guérin (BCG) is the standard intravesical treatment of high-risk noninvasive (Ta, T1, Tis) bladder cancer. Maintenance BCG is recommended for maximum efficacy. Objective: We compared our results in a large cohort of high-risk bladder cancer patients who received BCG without maintenance with published results from randomized maintenance BCG trials. Design, setting, and participants: A cohort of 1021 patients underwent restaging transurethral resection for high-risk (Ta, T1, Tis) bladder cancer. Intervention: Patients received a 6-wk induction course of BCG therapy. Responding patients did not receive maintenance BCG. Relapsing patients were eligible for retreatment with BCG. All patients were followed for a minimum of 5 yr. Measurements: End points were 5-yr tumor- and progression-free survival rates. Results and limitations: Of 816 complete responders to induction BCG, 2- and 5-yr recurrence-free survival rates were 73% and 46%, respectively. The progression-free survival rate was 89%. Progression-free survival time was 56 mo (95% confidence interval, 55-58 mo). Thirty-two percent of the patients required another course of BCG therapy. We cannot exclude that maintenance BCG may benefit patients beyond 5 yr over induction BCG alone and selective BCG retreatments. Conclusions: Our results with BCG treatment without maintenance of patients with high-risk non-muscle-invasive bladder cancer compare favorably with trials in which comparable patients received maintenance BCG. © 2011 European Association of Urology. Published by Elsevier B.V. All rights reserved. |
| Keywords: | bladder cancer; bcg; mainetenance |
| Journal Title: | European Urology |
| Volume: | 60 |
| Issue: | 1 |
| ISSN: | 0302-2838 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2011-07-01 |
| Start Page: | 32 |
| End Page: | 36 |
| Language: | English |
| DOI: | 10.1016/j.eururo.2011.03.051 |
| PROVIDER: | scopus |
| PUBMED: | 21497431 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 23 June 2011" - "CODEN: EUURA" - "Source: Scopus" |
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