EBV-associated lymphoepithelioma-like carcinoma of the pancreas: Case report with targeted sequencing analysis Journal Article
| Authors: | Samdani, R. T.; Hechtman, J. F.; O'reilly, E.; DeMatteo, R.; Sigel, C. S. |
| Article Title: | EBV-associated lymphoepithelioma-like carcinoma of the pancreas: Case report with targeted sequencing analysis |
| Abstract: | Lymphoepithelioma-like carcinomas are distinctive epithelial derived malignant neoplasms that have a syncytial growth pattern and lymphoid stroma. The majority of tumors with this appearance are Epstein Barr virus (EBV)-associated. We report a patient with a clinical presentation concerning for lymphoma who was diagnosed with an EBV-associated pancreatic carcinoma with a lymphoepithelioma-like pattern. Targeted sequencing analysis showed a molecular profile distinct from conventional ductal adenocarcinoma of the pancreas. © 2015 IAP and EPC. |
| Keywords: | adult; human tissue; middle aged; cancer surgery; unclassified drug; somatic mutation; clinical feature; case report; nuclear magnetic resonance imaging; pancreaticoduodenectomy; disease association; differential diagnosis; protein; cell population; histology; fever; pancreas carcinoma; in situ hybridization; pancreatitis; cancer size; lymphoma; virus load; cytokeratin; lymphocytic infiltration; cd3+ t lymphocyte; protein mlh1; protein msh2; protein msh6; lymphoepithelioma; lymphadenopathy; epstein barr virus; mismatch repair protein pms2; superior mesenteric artery; lymphoid cell; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1; pancreas metastasis; brca1 associated ring domain protein 1; fine needle aspiration biopsy; epstein barr virus infection; next generation sequencing; lymphoepithelioma-like carcinoma; human; male; priority journal; article; ebv-associated carcinoma; lymphoepithelial-like carcinoma; targeted molecular analysis; protein fat1; protein inpp4; epstein barr virus associated lymphoepithelioma like pancreas carcinoma; submandibular lymph node |
| Journal Title: | Pancreatology |
| Volume: | 15 |
| Issue: | 3 |
| ISSN: | 1424-3903 |
| Publisher: | Karger |
| Date Published: | 2015-05-01 |
| Start Page: | 302 |
| End Page: | 304 |
| Language: | English |
| DOI: | 10.1016/j.pan.2015.03.016 |
| PROVIDER: | scopus |
| PUBMED: | 25922198 |
| PMCID: | PMC5029421 |
| DOI/URL: | |
| Notes: | Export Date: 2 July 2015 -- Source: Scopus |
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