Updates on the genomics of bladder cancer and novel molecular taxonomy Review
| Authors: | Al-Ahmadie, H.; Netto, G. J. |
| Review Title: | Updates on the genomics of bladder cancer and novel molecular taxonomy |
| Abstract: | Urothelial carcinoma (UC) is the most common malignant neoplasm of the bladder that encompasses a wide spectrum of histopathologic features and various molecular alterations and subtypes, responsible for its significant morphologic and genomic heterogeneity. Morphologically, in addition to classic UC (not otherwise specified), many well documented variant histologies are a common finding in invasive UC, and include squamous, glandular, micropapillary, sarcomatoid, small cell/neuroendocrine, clear cell, lymphoepithelioma-like, and plasmacytoid types, among others. This review provides an update on the recent advances in the molecular characterization and novel molecular taxonomy of UC and variant histologies. © 2019 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | immunohistochemistry; signal transduction; gene mutation; overall survival; single nucleotide polymorphism; review; dna repair; gene overexpression; hepatocyte nuclear factor 3alpha; transcription factor gata 3; cell differentiation; bladder cancer; fibroblast growth factor receptor 3; protein p53; uvomorulin; histology; molecular typing; urothelial carcinoma; genomics; down regulation; cyclin dependent kinase inhibitor 2a; epidermal growth factor receptor 3; chromogranin; transitional cell carcinoma; peroxisome proliferator activated receptor gamma; divergent differentiation; lymphoepithelioma; dna helicase; neuroendocrine carcinoma; small cell; programmed death 1 ligand 1; neuroendocrine; micropapillary; squamous; e1a associated p300 protein; epithelial mesenchymal transition; germline mutation; janus kinase 3; plasmacytoid; molecular subtypes; tcga; taxonomy; cyclic amp responsive element binding protein binding protein; human; priority journal; whole exome sequencing; variant histology; apolipoprotein b mrna editing enzyme catalytic polypeptide like; desmocollin; desmoglein |
| Journal Title: | Advances in Anatomic Pathology |
| Volume: | 27 |
| Issue: | 1 |
| ISSN: | 1072-4109 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2020-01-01 |
| Start Page: | 36 |
| End Page: | 43 |
| Language: | English |
| DOI: | 10.1097/pap.0000000000000252 |
| PUBMED: | 31743118 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
