Updates on the genetics and molecular subtypes of urothelial carcinoma and select variants Journal Article


Authors: Al-Ahmadie, H.; Iyer, G.
Article Title: Updates on the genetics and molecular subtypes of urothelial carcinoma and select variants
Abstract: Urothelial carcinoma is a morphologically and genomically heterogeneous disease that exhibits a wide spectrum of morphologic features and molecular alterations and subtypes. Classic urothelial carcinoma (not otherwise specified) is the most common tumor type that develops in the urinary bladder but many, well-documented, variant histologies are commonly encountered in approximately one-third of invasive urothelial carcinoma, including squamous, glandular, micropapillary, sarcomatoid, small cell/neuroendocrine, clear cell, lymphoepithelioma-like, and plasmacytoid types, among others. In this review, we provide an update on the molecular advances in urothelial carcinoma and some of its variant histologies. © 2018 Elsevier Inc.
Keywords: urothelial carcinoma; divergent differentiation; small cell; neuroendocrine; micropapillary; squamous; plasmacytoid; variant histology
Journal Title: Surgical Pathology Clinics
Volume: 11
Issue: 4
ISSN: 1875-9181
Publisher: Elsevier Inc.  
Date Published: 2018-12-01
Start Page: 713
End Page: 723
Language: English
DOI: 10.1016/j.path.2018.07.011
PUBMED: 30447837
PROVIDER: scopus
DOI/URL:
Notes: Review -- Export Date: 3 December 2018 -- Source: Scopus
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MSK Authors
  1. Gopakumar Vasudeva Iyer
    143 Iyer