Extra-embryonic Wnt3 regulates the establishment of the primitive streak in mice Journal Article
| Authors: | Yoon, Y.; Huang, T.; Tortelote, G. G.; Wakamiya, M.; Hadjantonakis, A. K.; Behringer, R. R.; Rivera-Pérez, J. A. |
| Article Title: | Extra-embryonic Wnt3 regulates the establishment of the primitive streak in mice |
| Abstract: | The establishment of the head to tail axis at early stages of development is a fundamental aspect of vertebrate embryogenesis. In mice, experimental embryology, genetics and expression studies have suggested that the visceral endoderm, an extra-embryonic tissue, plays an important role in anteroposterior axial development. Here we show that absence of Wnt3 in the posterior visceral endoderm leads to delayed formation of the primitive streak and that interplay between anterior and posterior visceral endoderm restricts the position of the primitive streak. Embryos lacking Wnt3 in the visceral endoderm, however, appear normal by E9.5. Our results suggest a model for axial development in which multiple signals are required for anteroposterior axial development in mammals. © 2015 Elsevier Inc. |
| Keywords: | controlled study; protein expression; nonhuman; protein function; mouse; mammalia; animal tissue; mus; embryo; embryo development; vertebrata; mammal; endoderm; gastrulation; anterior posterior axis; primitive streak; wnt3 protein; priority journal; article; axial specification; wnt3 |
| Journal Title: | Developmental Biology |
| Volume: | 403 |
| Issue: | 1 |
| ISSN: | 0012-1606 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-07-01 |
| Start Page: | 80 |
| End Page: | 88 |
| Language: | English |
| DOI: | 10.1016/j.ydbio.2015.04.008 |
| PROVIDER: | scopus |
| PMCID: | PMC4469491 |
| PUBMED: | 25907228 |
| DOI/URL: | |
| Notes: | Export Date: 2 July 2015 -- Source: Scopus |
