The cell-intrinsic circadian clock is dispensable for lymphocyte differentiation and function Journal Article
| Authors: | Hemmers, S.; Rudensky, A. Y. |
| Article Title: | The cell-intrinsic circadian clock is dispensable for lymphocyte differentiation and function |
| Abstract: | Circadian rhythms regulate many aspects of physiology, ranging from sleep-wake cycles and metabolic parameters to susceptibility to infection. The molecular clock, with transcription factor BMAL1 at its core, controls both central and cell-intrinsic circadian rhythms. Using a circadian reporter, we observed dynamic regulation of clock activity in lymphocytes. However, its disruption upon conditional Bmal1 ablation did not alter T- or B-cell differentiation or function. Although the magnitude of interleukin 2 (IL-2) production was affected by the time of bacterial infection, it was independent of cell-intrinsic expression of BMAL1. The circadian gating of the IL-2 response was preserved in Bmal1-deficient T cells, despite a slight reduction in cytokine production in a competitive setting. Our results suggest that, contrary to the prevailing view, the adaptive immune response is not affected by the cell-intrinsic clock but is likely influenced by cell-extrinsic circadian cues operating across multiple cell types. © 2015 The Authors. |
| Keywords: | controlled study; protein expression; nonhuman; protein function; t lymphocyte; animal cell; mouse; cell function; interleukin 2; animal experiment; animal model; bacteria (microorganisms); b lymphocyte; lymphocyte differentiation; immune response; regulatory mechanism; protein synthesis; cytokine production; adaptive immunity; disease predisposition; listeriosis; cell selection; lymphocyte function; circadian rhythm; experimental autoimmune encephalomyelitis; priority journal; article; transcription factor arntl |
| Journal Title: | Cell Reports |
| Volume: | 11 |
| Issue: | 9 |
| ISSN: | 2211-1247 |
| Publisher: | Cell Press |
| Date Published: | 2015-06-09 |
| Start Page: | 1339 |
| End Page: | 1349 |
| Language: | English |
| DOI: | 10.1016/j.celrep.2015.04.058 |
| PROVIDER: | scopus |
| PMCID: | PMC4464971 |
| PUBMED: | 26004187 |
| DOI/URL: | |
| Notes: | Export Date: 2 July 2015 -- Source: Scopus |
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