T reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation Journal Article
| Authors: | Hemmers, S.; Schizas, M.; Rudensky, A. Y. |
| Article Title: | T reg cell-intrinsic requirements for ST2 signaling in health and neuroinflammation |
| Abstract: | ST2, the receptor for the alarmin IL-33, is expressed by a subset of regulatory T (T reg) cells residing in nonlymphoid tissues, and these cells can potently expand upon provision of exogenous IL-33. Whether the accumulation and residence of T reg cells in tissues requires their cell-intrinsic expression of and signaling by ST2, or whether indirect IL-33 signaling acting on other cells suffices, has been a matter of contention. Here, we report that ST2 expression on T reg cells is largely dispensable for their accumulation and residence in nonlymphoid organs, including the visceral adipose tissue (VAT), even though cell-intrinsic sensing of IL-33 promotes type 2 cytokine production by VAT-residing T reg cells. In addition, we uncovered a novel ST2-dependent role for T reg cells in limiting the size of IL-17A-producing γδT cells in the CNS in a mouse model of neuroinflammation, experimental autoimmune encephalomyelitis (EAE). Finally, ST2 deficiency limited to T reg cells led to disease exacerbation in EAE. © 2020 Hemmers et al. |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 218 |
| Issue: | 2 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 2021-02-01 |
| Start Page: | e20201234 |
| Language: | English |
| DOI: | 10.1084/jem.20201234 |
| PUBMED: | 33095261 |
| PROVIDER: | scopus |
| PMCID: | PMC7590508 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2020 -- Source: Scopus |
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