Blood pressure regulation through circadian variation: PRDM16 as a target in vascular smooth muscle cells Editorial

   


Authors: Cuibus, M. A.; Abdel-Wahab, O.
Title: Blood pressure regulation through circadian variation: PRDM16 as a target in vascular smooth muscle cells
Abstract: The precise mechanisms of blood pressure (BP) regulation are not fully elucidated, and understanding BP regulation is crucial for managing hypertension and improving outcomes for cardiovascular disease. In this issue of the JCI, Wang et al. identified the transcription factor PR domain–containing protein 16 (PRDM16) as a regulator of both vascular smooth muscle cell contraction and the circadian response to BP control. PRDM16 directly transcriptionally controlled the expression of the adrenergic receptor α 1d and several clock genes crucial for BP circadian regulation. These findings identify a mechanism of how molecular pathways govern circadian BP variation, highlighting PRDM16 as a potential target for hypertension. Copyright: © 2025, Cuibus et al.
Keywords: dna binding protein; genetics; dna-binding proteins; review; hypertension; nonhuman; mouse; animal; metabolism; animals; mice; animal tissue; transcription factor; transcription factors; gene expression regulation; blood pressure; drug therapy; muscle, smooth, vascular; vascular smooth muscle; circadian rhythm; blood pressure regulation; myocytes, smooth muscle; humans; human; vascular smooth muscle cell; smooth muscle cell; special situation for pharmacovigilance; receptors, adrenergic, alpha-1; alpha 1 adrenergic receptor; prdm16 protein, human; prdm16 protein, mouse; muscle fiber contraction
Journal Title: Journal of Clinical Investigation
Volume: 135
Issue: 3
ISSN: 0021-9738
Publisher: American Society for Clinical Investigation  
Date Published: 2025-02-03
Start Page: e188784
Language: English
DOI: 10.1172/jci188784
PUBMED: 39895629
PROVIDER: scopus
PMCID: PMC11785916
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85217481253&doi=10.1172%2fJCI188784&partnerID=40&md5=62f36f7b32c385ef75785fcf7d820216
Notes: Review -- Source: Scopus
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MSK Authors
  1. Omar Ibrahim Abdel-Wahab
    573 Abdel-Wahab
  2. Maria Adriana Cuibus
    1 Cuibus
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