Simultaneous resection for rectal cancer with synchronous liver metastasis is a safe procedure Journal Article


Authors: Silberhumer, G. R.; Paty, P. B.; Temple, L. K.; Araujo, R. L. C. ; Denton, B.; Gonen, M.; Nash, G. M.; Allen, P. J.; DeMatteo, R. P.; Guillem, J.; Weiser, M. R.; D'Angelica, M. I.; Jarnagin, W. R.; Wong, D. W.; Fong, Y.
Article Title: Simultaneous resection for rectal cancer with synchronous liver metastasis is a safe procedure
Abstract: Background One quarter of colorectal cancer patients will present with liver metastasis at the time of diagnosis. Recent studies have shown that simultaneous resections are safe and feasible for stage IV colon cancer. Limited data are available for simultaneous surgery in stage IV rectal cancer patients. Methods One hundred ninety-eight patients underwent surgical treatment for stage IV rectal cancer. In 145 (73%) patients, a simultaneous procedure was performed. Fifty-three (27%) patients underwent staged liver resection. A subpopulation of 69 (35%) patients underwent major liver resection (3 segments or more) and 30 (44%) patients with simultaneous surgery. Results The demographics of the 2 groups were similar. Complication rates were comparable for simultaneous or staged resections, even in the group subjected to major liver resection. Total hospital stay was significantly shorter for the simultaneously resected patients (P <.01). Conclusions Simultaneous resection of rectal primaries and liver metastases is a safe procedure in carefully selected patients at high-volume institutions, even if major liver resections are required. © 2015 Elsevier Inc.
Keywords: adult; cancer surgery; major clinical study; fistula; gastrointestinal hemorrhage; adjuvant therapy; cancer adjuvant therapy; cancer patient; laparotomy; dehydration; cancer mortality; risk assessment; postoperative complication; liver metastasis; hospitalization; disease severity; feasibility study; pneumothorax; cardiovascular disease; cancer size; operation duration; bile leakage; urinary tract infection; comorbidity; blood transfusion; liver resection; complications; colitis; wound infection; rectum cancer; ileus; urine retention; liver injury; rectum resection; abdominal wall hernia; abscess; peroperative complication; effusion; operative blood loss; human; male; female; priority journal; article; tertiary care center; simultaneous resection; stage iv rectal cancer; gastrointestinal leakage
Journal Title: American Journal of Surgery
Volume: 209
Issue: 6
ISSN: 0002-9610
Publisher: Elsevier Inc.  
Date Published: 2015-06-01
Start Page: 935
End Page: 942
Language: English
DOI: 10.1016/j.amjsurg.2014.09.024
PROVIDER: scopus
PUBMED: 25601556
PMCID: PMC4603659
DOI/URL:
Notes: Export Date: 2 July 2015 -- Source: Scopus
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MSK Authors
  1. Brian Denton
    10 Denton
  2. Philip B Paty
    379 Paty
  3. Ronald P DeMatteo
    610 DeMatteo
  4. Mithat Gonen
    726 Gonen
  5. Jose Guillem
    379 Guillem
  6. Martin R Weiser
    351 Weiser
  7. Peter Allen
    449 Allen
  8. William R Jarnagin
    600 Jarnagin
  9. Yuman Fong
    746 Fong
  10. Garrett Nash
    141 Nash
  11. Larissa Temple
    185 Temple
  12. Douglas W Wong
    173 Wong