Timing of primary tumor resection in synchronous metastatic colon cancer patients undergoing hepatic arterial infusion pump placement Journal Article

   

Authors:	Verheij, F. S.; Soares, K. C.; Beets, G. L.; Kok, N. F. M.; Yuval, J. B.; Kemeny, N. E.; Kingham, T. P.; Jarnagin, W. R.; D’Angelica, M. I.; Garcia-Aguilar, J.
Article Title:	Timing of primary tumor resection in synchronous metastatic colon cancer patients undergoing hepatic arterial infusion pump placement
Abstract:	Introduction: Hepatic arterial infusion (HAI) chemotherapy is associated with improved survival in stage IV colon cancer with liver metastases. Whether simultaneous colon resection and HAI pump (HAIP) placement is associated with increased morbidity has not been specifically studied. The purpose of this study was to compare perioperative outcomes of simultaneous colon resection and HAIP placement versus HAIP placement alone. Methods: This was a retrospective study of consecutive patients with colon cancer and synchronous liver metastases who underwent HAIP placement between 2007 and 2018. Clinicopathologic characteristics, operative data, complications, and time to first cycle of HAIP chemotherapy were compared between patients who underwent colon resection simultaneously with HAIP placement and those who underwent HAIP placement alone. Results: A total of 258 patients underwent simultaneous colectomy and HAIP placement, and 116 patients underwent HAIP placement alone. Grade 1–2 complications were more common in patients who underwent simultaneous colectomy and HAIP placement (36.8% vs. 19.0%, P < 0.001), but grade 3–4 complications were not observed more frequently (14.3% vs. 12.9%, P = 0.872). The median interval between HAIP placement and start of HAIP chemotherapy did not differ between groups (simultaneous colectomy, 27 days [interquartile range (IQR) 17–34]; HAIP placement alone, 30 days [IQR 21–34]; P = 0.924). Infection of the pump causing either delay of initiation of chemotherapy or explantation of the pump occurred in five patients with simultaneous colectomy and in one patient with HAIP placement alone (P = 0.671). Conclusions: Simultaneous HAIP implantation and colectomy is safe in patients with liver metastases of colon carcinoma. © 2021, Society of Surgical Oncology.
Keywords:	adult; cancer chemotherapy; treatment outcome; cancer surgery; primary tumor; retrospective studies; major clinical study; clinical feature; ascites; liver neoplasms; comparative study; chemotherapy, adjuvant; laparotomy; computer assisted tomography; bleeding; colonic neoplasms; cohort analysis; continuous infusion; explant; retrospective study; carcinogenesis; lung embolism; postoperative complication; colorectal neoplasms; hypotension; liver failure; length of stay; liver metastasis; body mass; thromboembolism; colorectal tumor; adjuvant chemotherapy; colon tumor; liver tumor; operation duration; therapy delay; bile leakage; reoperation; surgical infection; comorbidity; arteriography; colon resection; liver resection; intermethod comparison; hepatectomy; pleura effusion; heart arrhythmia; cholecystectomy; anastomosis; hematoma; floxuridine; cholecystitis; implantation; infusion pumps, implantable; colectomy; peroperative complication; hypertransaminasemia; artery dissection; device infection; demographics; urinary dysfunction; aneurysm; paralytic ileus; failure to thrive; metastatic colon cancer; medical device complication; humans; human; male; female; article; extrahepatic perfusion; abdominal wound closure; american society of anaesthesiologists score; pump infection; implantable infusion pump
Journal Title:	Annals of Surgical Oncology
Volume:	29
Issue:	3
ISSN:	1068-9265
Publisher:	Springer
Date Published:	2022-03-01
Start Page:	2044
End Page:	2051
Language:	English
DOI:	10.1245/s10434-021-11029-3
PUBMED:	34751873
PROVIDER:	scopus
PMCID:	PMC8896144
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118687614&doi=10.1245%2fs10434-021-11029-3&partnerID=40&md5=db9f98a4226c8a01df531cd434f08c7f
Notes:	Article -- Export Date: 1 March 2022 -- Source: Scopus

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