T cell exclusion, immune privilege, and the tumor microenvironment Journal Article
| Authors: | Joyce, J. A.; Fearon, D. T. |
| Article Title: | T cell exclusion, immune privilege, and the tumor microenvironment |
| Abstract: | Effective immunotherapy promotes the killing of cancer cells by cytotoxic T cells. This requires not only that cancer-specific Tcells be generated, but also that these Tcells physically contact cancer cells. The coexistence in some patients of cancer cells and T cells that recognize them indicates that tumors may exhibit the phenomenon of immune privilege, in which immunogenic tissue is protected from immune attack. Here, we review the evidence that stromal cells of the tumor microenvironment mediate this restriction by excluding T cells from the vicinity of cancer cells. Overcoming this T cell checkpoint may thus enable optimal immunotherapy. |
| Keywords: | vasculotropin; protein expression; review; monotherapy; nonhuman; disease free survival; neoplasms; colorectal cancer; cd8+ t lymphocyte; lymphocyte proliferation; t lymphocyte; tumor associated leukocyte; mouse; animal; cytology; animals; mice; cytotoxic t lymphocyte antigen 4 antibody; cancer immunotherapy; ovary cancer; fas ligand; granulocyte macrophage colony stimulating factor; interleukin 10; neovascularization, pathologic; vascularization; prostate cancer; cancer inhibition; immunological tolerance; immunology; immune tolerance; immune response; tumor necrosis factor alpha; immunotherapy; gamma interferon; melanoma antigen 1; glioblastoma; cancer cell; prostaglandin e2; tumor necrosis factor related apoptosis inducing ligand; cytotoxic t lymphocyte; t-lymphocytes, cytotoxic; recurrent disease; pancreas adenocarcinoma; chimeric antigen receptor; lymphoproliferative disease; tumor; phagocytosis; cytokine release; immunosuppressive treatment; stroma cell; stromal cells; tumor vascularization; cell interaction; neovascularization (pathology); cytomegalovirus infection; chemokine receptor ccr2; interleukin 12; epstein barr virus; monocyte chemotactic protein 1; programmed death 1 ligand 1; tumor microenvironment; tumor immunology; chemokine receptor cxcr4; reactive nitrogen species; rantes; procedures; cancer; humans; human; priority journal; endothelin b receptor |
| Journal Title: | Science |
| Volume: | 348 |
| Issue: | 6230 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2015-04-01 |
| Start Page: | 74 |
| End Page: | 80 |
| Language: | English |
| DOI: | 10.1126/science.aaa6204 |
| PUBMED: | 25838376 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 3 June 2015 -- Source: Scopus |
