CAR T-cell therapy for pleural mesothelioma: Rationale, preclinical development, and clinical trials Review

   


Authors: Chintala, N. K.; Restle, D.; Quach, H.; Saini, J.; Bellis, R.; Offin, M.; Beattie, J.; Adusumilli, P. S.
Review Title: CAR T-cell therapy for pleural mesothelioma: Rationale, preclinical development, and clinical trials
Abstract: The aim of adoptive T-cell therapy is to promote tumor-infiltrating immune cells following the transfer of either tumor-harvested or genetically engineered T lymphocytes. A new chapter in adoptive T-cell therapy began with the success of chimeric antigen receptor (CAR) T-cell therapy. T cells harvested from peripheral blood are transduced with genetically engineered CARs that render the ability to recognize cancer cell-surface antigen and lyse cancer cells. The successes in CAR T-cell therapy for B-cell leukemia and lymphoma have led to efforts to expand this therapy to solid tumors. Herein, we discuss the rationale behind the preclinical development and clinical trials of T-cell therapies in patients with malignant pleural mesothelioma. Furthermore, we highlight the ongoing investigation of combination immunotherapy strategies to synergistically potentiate endogenous as well as adoptively transferred immunity. © 2021 Elsevier B.V.
Keywords: lung neoplasms; lung tumor; mesothelioma; adoptive cell therapy; pleura tumor; malignant pleural mesothelioma; pleural neoplasms; adoptive immunotherapy; immunotherapy, adoptive; humans; human; pleural cancers; locoregional delivery; mesothelioma, malignant
Journal Title: Lung Cancer
Volume: 157
ISSN: 0169-5002
Publisher: Elsevier Ireland Ltd.  
Date Published: 2021-07-01
Start Page: 48
End Page: 59
Language: English
DOI: 10.1016/j.lungcan.2021.05.004
PUBMED: 33972125
PROVIDER: scopus
PMCID: PMC8184643
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105535681&doi=10.1016%2fj.lungcan.2021.05.004&partnerID=40&md5=220a4c025ef5e3ec37b224083cf515e8
Notes: Review -- Export Date: 2 August 2021 -- Source: Scopus
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MSK Authors
  1. Prasad S Adusumilli
    496 Adusumilli
  2. Navin Kumar Chintala
    27 Chintala
  3. Michael David Offin
    170 Offin
  4. Jasmeen Kaur Saini
    12 Saini
  5. Tu Hue Quach
    8 Quach
  6. Jason Anthony Beattie
    22 Beattie
  7. Rebecca Bellis
    11 Bellis
  8. David Joseph Restle
    4 Restle
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