Chimeric antigen receptor (CAR) T-cell therapy for thoracic malignancies Journal Article

   


Authors: Kiesgen, S.; Chicaybam, L.; Chintala, N. K.; Adusumilli, P. S.
Article Title: Chimeric antigen receptor (CAR) T-cell therapy for thoracic malignancies
Abstract: Chimeric antigen receptor (CAR) T cells are patient T cells that are transduced with genetically engineered synthetic receptors to target a cancer cell surface antigen. The remarkable clinical response rates achieved by adoptive transfer of T cells that target CD19 in patients with leukemia and lymphoma have led to a growing number of clinical trials exploring CAR T-cell therapy for solid tumors. Herein, we review the evolution of adoptive T-cell therapy; highlight advances in CAR T-cell therapy for thoracic malignancies; and summarize the targets being investigated in clinical trials for patients with lung cancer, malignant pleural mesothelioma, and esophageal cancer. We further discuss the barriers to successfully translating CAR T-cell therapy for solid tumors and present strategies that have been investigated to overcome these hurdles. © 2017 International Association for the Study of Lung Cancer
Keywords: cancer survival; protein expression; treatment outcome; treatment response; review; nonhuman; neurotoxicity; t lymphocyte; tumor associated leukocyte; interleukin 2; cancer immunotherapy; protein targeting; carcinoembryonic antigen; epidermal growth factor receptor; epidermal growth factor receptor 2; lung cancer; lymphocyte activation; seprase; immunotherapy; pleura mesothelioma; adoptive cell therapy; chimeric antigen receptor; cell therapy; clinical effectiveness; epithelial cell adhesion molecule; antigen binding; major histocompatibility complex; esophagus cancer; adoptive immunotherapy; cd28 antigen; brain edema; major histocompatibility antigen class 1; non small cell lung cancer; t-cell therapy; glypican 3; cytokine release syndrome; thorax cancer; cd3 antibody; human; priority journal; receptor tyrosine kinase like orphan receptor; thoracic cancers
Journal Title: Journal of Thoracic Oncology
Volume: 13
Issue: 1
ISSN: 1556-0864
Publisher: Elsevier Inc.  
Date Published: 2018-01-01
Start Page: 16
End Page: 26
Language: English
DOI: 10.1016/j.jtho.2017.10.001
PROVIDER: scopus
PMCID: PMC5738277
PUBMED: 29107016
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039964384&doi=10.1016%2fj.jtho.2017.10.001&partnerID=40&md5=9be3744a0938b3d96a8fae4951a7010d
Notes: Review -- Export Date: 1 February 2018 -- Source: Scopus
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MSK Authors
  1. Prasad S Adusumilli
    496 Adusumilli
  2. Navin Kumar Chintala
    27 Chintala
  3. Leonardo Chicaybam Peixoto
    2 Chicaybam Peixoto
  4. Stefan Thomas Kiesgen
    5 Kiesgen
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