Novel directions in neoadjuvant therapy for pancreas adenocarcinoma Journal Article
| Authors: | Yang, A.; O'Reilly, E. M. |
| Article Title: | Novel directions in neoadjuvant therapy for pancreas adenocarcinoma |
| Abstract: | Surgical resection of pancreatic carcinoma has long represented the only viable option for a potential cure of pancreas cancer. The use of adjuvant chemotherapy post-resection has been established in treating micro metastases and prolonging disease-free survival. However, studies of neoadjuvant therapy have not come to any definitive conclusion regarding the overall efficacy of such treatment, despite the theoretical benefits. In this review, we examine the historical precedent as well as the current state of affairs regarding neoadjuvant therapy in resectable and borderline resectable pancreatic adenocarcinoma. In addition, we review the definitions for resectable and borderline resectable disease and highlight key areas of clinical investigation in the field and summarize the major ongoing neoadjuvant studies focused on resectable pancreatic adenocarcinoma. © 2015 Informa UK, Ltd. |
| Keywords: | treatment response; survival rate; unclassified drug; overall survival; review; cisplatin; erlotinib; fluorouracil; diarrhea; monotherapy; capecitabine; gemcitabine; paclitaxel; cancer adjuvant therapy; cancer radiotherapy; disease free survival; neurotoxicity; antineoplastic agent; ipilimumab; progression free survival; quality of life; bone marrow suppression; stomatitis; thrombocytopenia; cyclophosphamide; docetaxel; irinotecan; gastrointestinal toxicity; folinic acid; pancreas adenocarcinoma; pancreatic cancer; granulocyte macrophage colony stimulating factor vaccine; oxaliplatin; neoadjuvant; adjuvant; randomized controlled trial (topic); phase 2 clinical trial (topic); meta analysis (topic); phase 3 clinical trial (topic); phase 1 clinical trial (topic); pancreas surgery; cp 870893; gimeracil plus oteracil potassium plus tegafur; nivolumab; human; algenpantucel l; borderline respectable; folfirinox; crs 207 |
| Journal Title: | Expert Review of Gastroenterology and Hepatology |
| Volume: | 9 |
| Issue: | 5 |
| ISSN: | 1747-4124 |
| Publisher: | Informa Healthcare |
| Date Published: | 2015-05-01 |
| Start Page: | 585 |
| End Page: | 601 |
| Language: | English |
| DOI: | 10.1586/17474124.2015.1012496 |
| PROVIDER: | scopus |
| PUBMED: | 25686370 |
| DOI/URL: | |
| Notes: | Export Date: 3 June 2015 -- Source: Scopus |
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