CT imaging assessment of pancreatic adenocarcinoma resectability after neoadjuvant Therapy: Current status and perspective on the use of radiomics Review

   

Authors:	Khasawneh, H.; Ferreira Dalla Pria, H. R.; Miranda, J.; Nevin, R.; Chhabra, S.; Hamdan, D.; Chakraborty, J.; Biachi de Castria, T.; Horvat, N.
Review Title:	CT imaging assessment of pancreatic adenocarcinoma resectability after neoadjuvant Therapy: Current status and perspective on the use of radiomics
Abstract:	Pancreatic adenocarcinoma (PDAC) is the most common pancreatic cancer and is associated with poor prognosis, a high mortality rate, and a substantial number of healthy life years lost. Surgical resection is the primary treatment option for patients with resectable disease; however, only 10–20% of all patients with PDAC are eligible for resection at the time of diagnosis. In this context, neoadjuvant therapy has the potential to increase the number of patients who are eligible for resection, thereby improving the overall survival rate. For patients who undergo neoadjuvant therapy, computed tomography (CT) remains the primary imaging tool for assessing treatment response. Nevertheless, the interpretation of imaging findings in this context remains challenging, given the similarity between viable tumor and treatment-related changes following neoadjuvant therapy. In this review, following an overview of the various treatment options for PDAC according to its resectability status, we will describe the key challenges regarding CT-based evaluation of PDAC treatment response following neoadjuvant therapy, as well as summarize the literature on CT-based evaluation of PDAC treatment response, including the use of radiomics. Finally, we will outline key recommendations for the management of PDAC after neoadjuvant therapy, taking into consideration CT-based findings. © 2023 by the authors.
Keywords:	treatment response; neoadjuvant therapy; pancreatic cancer; computed tomography; radiomics
Journal Title:	Journal of Clinical Medicine
Volume:	12
Issue:	21
ISSN:	2077-0383
Publisher:	MDPI
Date Published:	2023-11-01
Start Page:	6821
Language:	English
DOI:	10.3390/jcm12216821
PROVIDER:	scopus
PMCID:	PMC10649102
PUBMED:	37959287
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85176565418&doi=10.3390%2fjcm12216821&partnerID=40&md5=ae3cf1280b4d631dd97de728a4d480b3
Notes:	The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding MSK author is Natally Horvat -- MSK author Joao Manoel Miranda Magalhaes Santos's name is listed as simply 'Joao Miranda' on the original publication -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/211428