Selective modulation of the functions of a conserved DNA motor by a histone fold complex Journal Article
| Authors: | Xue, X.; Choi, K.; Bonner, J. N.; Szakal, B.; Chen, Y. H.; Papusha, A.; Saro, D.; Niu, H.; Ira, G.; Branzei, D.; Sung, P.; Zhao, X. |
| Article Title: | Selective modulation of the functions of a conserved DNA motor by a histone fold complex |
| Abstract: | Budding yeast Mph1 helicase and its orthologs drive multiple DNA transactions. Elucidating the mechanisms that regulate these motor proteins is central to understanding genome maintenance processes. Here, we show that the conserved histone fold MHF complex promotes Mph1mediated repair of damaged replication forks but does not influence the outcome of DNA double-strand break repair. Mechanistically, scMHF relieves the inhibition imposed by the structural maintenance of chromosome protein Smc5 on Mph1 activities relevant to replicationassociated repair through binding to Mph1 but not DNA. Thus, scMHF is a function-specific enhancer of Mph1 that enables flexible response to different genome repair situations. © 2015 Xue et al. |
| Keywords: | homologous recombination; dna motor proteins; genome replication; histone fold proteins; replication fork repair; structural maintenance of chromosome proteins |
| Journal Title: | Genes and Development |
| Volume: | 29 |
| Issue: | 10 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2015-05-15 |
| Start Page: | 1000 |
| End Page: | 1005 |
| Language: | English |
| DOI: | 10.1101/gad.259143.115 |
| PROVIDER: | scopus |
| PMCID: | PMC4441048 |
| PUBMED: | 25956905 |
| DOI/URL: | |
| Notes: | Export Date: 3 June 2015 -- Source: Scopus |
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