| Abstract: |
Transcriptional activation by, and therefore the physiologic impact of, activated tyrosine-phosphorylated STATs (signal transducers and activators of transcription) may be negatively regulated by proteins termed PIAS (protein inhibitors of activated stats), as shown by previous experiments with mammalian cells in culture. Here, by using the genetic modifications in Drosophila, we demonstrate the in vivo functional interaction of the Drosophila homologues stat92E and a Drosophila PIAS gene (dpias). To this end we use a LOF allele and conditionally overexpressed dpias in JAK-STAT pathway mutant backgrounds. We conclude that the correct dpias/stat92E ratio is crucial for blood cell and eye development. |
| Keywords: |
signal transduction; controlled study; protein phosphorylation; unclassified drug; gene mutation; dna-binding proteins; nonhuman; proteins; mammalia; animals; animal tissue; alleles; drosophila; gene function; morphogenesis; in vivo study; phosphorylation; animalia; transcription factors; gene expression regulation, developmental; dna modification; transcription regulation; protein processing, post-translational; recombination, genetic; intracellular signaling peptides and proteins; carrier proteins; neoplasms, experimental; blood cell; protein-tyrosine kinases; trans-activators; drosophila melanogaster; sequence homology; drosophila proteins; mutagenesis, insertional; eye; protein dna interaction; hexapoda; eye development; stat protein; inhibitor protein; protein inhibitor of activated stat; janus kinases; eye abnormalities; stat transcription factors; protein inhibitors of activated stat; priority journal; article; arachnida; insect proteins; stat92e protein
|
