Reversible spastic paraparesis induced by high-dose intravenous methadone Journal Article
| Authors: | Manfredi, P. L.; Gonzales, G. R.; Payne, R. |
| Article Title: | Reversible spastic paraparesis induced by high-dose intravenous methadone |
| Abstract: | High doses of parenteral opioids can cause multifocal myoclonus and seizures. Spasticity has been reported in patients receiving intraspinal opioids. In this article, we describe a patient who developed reversible spastic paraparesis with prominent extensor spasms in the legs while receiving an infusion of intravenous methadone at 100 mg/hr. We discuss clinical presentation and possible pathophysiologic mechanisms of opioid side effects on the somatic motor system. |
| Keywords: | adult; clinical feature; case report; pain; seizure; methadone; myoclonus; opioid; toxicity; motor system; spastic paraplegia; spasticity; human; male; article; paraparesis |
| Journal Title: | Journal of Pain |
| Volume: | 2 |
| Issue: | 1 |
| ISSN: | 1526-5900 |
| Publisher: | Churchill Livingstone |
| Date Published: | 2001-02-01 |
| Start Page: | 77 |
| End Page: | 79 |
| Language: | English |
| DOI: | 10.1054/jpai.2001.9803 |
| PROVIDER: | scopus |
| PUBMED: | 14622789 |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
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