Human T-lymphotropic virus type I-associated myelopathy in patients with the acquired immunodeficiency syndrome Journal Article

  

Authors:	Rosenblum, M. K.; Brew, B. J.; Hahn, B.; Shaw, G.; Haase, A.; Maroushek, S.; Price, R. W.
Article Title:	Human T-lymphotropic virus type I-associated myelopathy in patients with the acquired immunodeficiency syndrome
Abstract:	We describe two cases of serologically confirmed human T-lymphotropic virus type I (HTLV-I)-associated myelopathy involving North American men coinfected by the human immunodeficiency virus type 1. Our first patient suffered from a gradually progressive spastic paraparesis for 10 years prior to presenting with Kaposi's sarcoma, while our second patient developed subacutely progressive spastic paraparesis in the setting of full-blown acquired immunodeficiency syndrome. Autopsy examination of the spinal cords from these two cases revealed widespread axonal loss and demyelination principally involving the lateral columns of case no. 1 and the lateral and anterior columns of case no. 2. Vascular sclerosis and hyalinization were prominent in both cases, but in neither was there a conspicuous inflammatory component. In case no. 2, HTLV-I mRNA was not detected by in situ hybridization, but HTLV-I proviral DNA sequences were detected in this case by polymerase chain reaction. Neither case exhibited multinucleated cell (human immunodeficiency virus type 1) myelitis, vacuolar myelopathy, or evidence of HTLV-II infection by polymerase chain reaction assay. © 1992.
Keywords:	adult; case report; polymerase chain reaction; dna recombination; gene amplification; pneumocystis pneumonia; molecular sequence data; immunoblotting; base sequence; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; kaposi sarcoma; autopsy; spinal cord disease; hiv-1; human t cell leukemia virus 1; human t-lymphotropic virus 1; middle age; virus dna; demyelination; spinal cord diseases; aids; spastic paraplegia; nerve fiber degeneration; myelopathy; arteriosclerosis; pleocytosis; hyaline degeneration; human; male; priority journal; article; support, u.s. gov't, p.h.s.; paraparesis, tropical spastic; htlv-i
Journal Title:	Human Pathology
Volume:	23
Issue:	5
ISSN:	0046-8177
Publisher:	Elsevier Inc.
Date Published:	1992-05-01
Start Page:	513
End Page:	519
Language:	English
DOI:	10.1016/0046-8177(92)90128-p
PUBMED:	1568747
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026740164&doi=10.1016%2f0046-8177%2892%2990128-P&partnerID=40&md5=5e13d639f60d7d1e96cbc7f7dbd6f42c
Notes:	Article -- Export Date: 30 July 2019 -- Source: Scopus

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