Incorporating prognostic information into treatment decisions in chronic lymphocytic leukemia Journal Article
| Authors: | Jain, N.; Lamanna, N. |
| Article Title: | Incorporating prognostic information into treatment decisions in chronic lymphocytic leukemia |
| Abstract: | Most patients with chronic lymphocytic leukemia are diagnosed at an early stage, when traditional staging systems fail to distinguish those with an aggressive disease course from those with an excellent prognosis. This failure underscores the need for better prognostic markers. Although many markers have been explored, this review focuses on the newer and most clinically relevant markers: cytogenetic aberrations, zeta-associated protein 70, immunoglobulin mutational status, and CD38 expression. Although these markers have been shown to predict outcomes for groups of patients, individual patients may have a variable course; therefore, the outcome for any one patient remains hard to predict. To date, no study has shown a benefit from early cytotoxic therapy for any subgroup of patients with chronic lymphocytic leukemia. © Current Medicine Group, LLC 2009. |
| Keywords: | protein expression; gene mutation; somatic mutation; gene deletion; mutation; fludarabine; clinical trial; review; disease classification; drug efficacy; rituximab; drug megadose; protein function; gene expression profiling; cell maturation; tumor markers, biological; cytogenetics; cyclophosphamide; protein p53; b lymphocyte; chromosome aberration; fluorescence in situ hybridization; immunoglobulin heavy chain; immunoglobulin variable region; immunoglobulin heavy chains; methylprednisolone; chromosome aberrations; chronic lymphatic leukemia; leukemia, lymphocytic, chronic, b-cell; protein kinase zap 70; alemtuzumab; cd38 antigen; chlorambucil; chromosome 11q; antigens, cd38; zap-70 protein-tyrosine kinase |
| Journal Title: | Current Oncology Reports |
| Volume: | 11 |
| Issue: | 5 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2009-09-01 |
| Start Page: | 353 |
| End Page: | 359 |
| Language: | English |
| DOI: | 10.1007/s11912-009-0048-9 |
| PUBMED: | 19679010 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "CODEN: CORUA" - "Source: Scopus" |
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