Chronic myelogenous leukemia, version 1.2015 Journal Article

  


Authors: O'Brien, S.; Radich, J. P.; Abboud, C. N.; Akhtari, M.; Altman, J. K.; Berman, E.; Curtin, P.; DeAngelo, D. J.; Deininger, M.; Devine, S.; Fathi, A. T.; Gotlib, J.; Jagasia, M.; Kropf, P.; Moore, J. O.; Pallera, A.; Reddy, V. V. B.; Shah, N. P.; Smith, B. D.; Snyder, D. S.; Wetzler, M.; Gregory, K.; Sundar, H.
Article Title: Chronic myelogenous leukemia, version 1.2015
Abstract: Chronic myelogenous leukemia (CML) is usually diagnosed in the chronic phase. Untreated chronic phase CML will eventually progress to advanced phase (accelerated or blast phase) CML. Tyrosine kinase inhibitors (TKIs) have been shown to induce favorable response rates in patients with accelerated and blast phase CML. The addition of TKIs to chemotherapy has also been associated with improved outcomes in patients with blast phase CML. Allogeneic hematopoietic stem cell transplant remains a potentially curative option for patients with advanced phase CML, although treatment with a course of TKIs will be beneficial as a bridge to transplant. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of patients with advanced phase CML.
Keywords: cancer chemotherapy; treatment outcome; treatment response; doxorubicin; cytarabine; treatment indication; imatinib; cyclophosphamide; dexamethasone; vincristine; practice guideline; hematopoietic stem cell transplantation; dasatinib; chronic myeloid leukemia; protein tyrosine kinase inhibitor; patient care; daunorubicin; 5 aza 2' deoxycytidine; idarubicin; nilotinib; bosutinib; ponatinib; human; article
Journal Title: Journal of the National Comprehensive Cancer Network
Volume: 12
Issue: 11
ISSN: 1540-1405
Publisher: Harborside Press  
Date Published: 2014-11-01
Start Page: 1590
End Page: 1610
Language: English
PROVIDER: scopus
PUBMED: 25361806
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84908539399&partnerID=40&md5=f04ddb1796a82972a64df608f5576278
Notes: Export Date: 1 December 2014 -- Source: Scopus
Citation Impact
What is Dimensions Citation Badge?
MSK Authors
  1. Ellin Berman
    173 Berman
Related MSK Work