Chronic myeloid leukemia, version 2.2024, NCCN Clinical Practice Guidelines in Oncology Guidelines
| Authors: | Shah, N. P.; Bhatia, R.; Altman, J. K.; Amaya, M.; Begna, K. H.; Berman, E.; Chan, O.; Clements, J.; Collins, R. H. Jr; Curtin, P. T.; DeAngelo, D. J.; Drazer, M.; Maness, L.; Metheny, L.; Mohan, S.; Moore, J. O.; Oehler, V.; Pratz, K.; Pusic, I.; Rose, M. G.; Shomali, W.; Smith, B. D.; Styler, M.; Talpaz, M.; Tanaka, T. N.; Tantravahi, S.; Thompson, J.; Tsai, S.; Vaughn, J.; Welborn, J.; Yang, D. T.; Sundar, H.; Gregory, K. |
| Title: | Chronic myeloid leukemia, version 2.2024, NCCN Clinical Practice Guidelines in Oncology |
| Abstract: | Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome resulting from a reciprocal translocation between chromosomes 9 and 22 [t9;22] that gives rise to a BCR::ABL1 fusion gene. CML occurs in 3 different phases (chronic, accelerated, and blast phase) and is usually diagnosed in the chronic phase in developed countries. Tyrosine kinase inhibitor (TKI) therapy is a highly effective treatment option for patients with chronic phase-CML. The primary goal of TKI therapy in patients with chronic phase-CML is to prevent disease progression to accelerated phase-CML or blast phase-CML. Discontinuation of TKI therapy with careful monitoring is feasible in selected patients. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of patients with chronic phase-CML. |
| Keywords: | genetics; protein kinase inhibitor; chronic myeloid leukemia; protein kinase inhibitors; bcr abl protein; leukemia, myelogenous, chronic, bcr-abl positive; fusion proteins, bcr-abl; philadelphia 1 chromosome; blast cell crisis; myeloid leukemia; philadelphia chromosome; leukemia, myeloid, chronic-phase; blast crisis; humans; human |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 22 |
| Issue: | 1 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2024-02-01 |
| Start Page: | 43 |
| End Page: | 69 |
| Language: | English |
| DOI: | 10.6004/jnccn.2024.0007 |
| PUBMED: | 38394770 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
