Predictive factor for the response to adjuvant therapy with emphasis in breast cancer Journal Article
| Authors: | Munster, P. N.; Norton, L. |
| Article Title: | Predictive factor for the response to adjuvant therapy with emphasis in breast cancer |
| Abstract: | One of the major challenges of early-stage breast cancer is to select the adjuvant therapy that ensures the most benefits and the least harm for the patient. The definition of accurate predictive factors is therefore of paramount importance. So far the choice of adjuvant therapy has been based on the number of affected lymph nodes and the hormone receptor status of the patient. This paper evaluates the use of other tumor-related markers as predictive factors for adjuvant therapy. These include HER2, p53 and Bcl-2, cathepsin B, p27, proliferating cell nuclear antigen (PCNA), cyclin D, Ki-67, and vascular endothelial growth factor (VEGF). |
| Keywords: | vasculotropin; cancer survival; controlled study; doxorubicin; fluorouracil; risk benefit analysis; adjuvant therapy; cancer adjuvant therapy; chemotherapy, adjuvant; methotrexate; cancer diagnosis; diagnostic accuracy; genetic analysis; ki 67 antigen; protein analysis; protein bcl 2; unindexed drug; vasculotropin receptor; breast cancer; antineoplastic combined chemotherapy protocols; tumor markers, biological; cyclophosphamide; melphalan; protein interaction; chemosensitivity; vasculotropin inhibitor; breast neoplasms; protein p53; tumor marker; monoclonal antibody; molecular marker; tumor suppressor gene; early cancer; gene interaction; lymph node; protein p27; drug response; tyrosine kinase receptor; predictive value of tests; tumor suppressor protein p53; epirubicin; receptor, erbb-2; cathepsin b; taxane derivative; cycline; estrogen receptor; progesterone receptor; trastuzumab; anthracycline; hormone receptor; cyclin d1; proto-oncogene proteins c-bcl-2; oncogene neu; predictive factors; drug choice; cytochrome c; dimer; apoptotic protease activating factor 1; humans; prognosis; human; female; article; oncogene c erb |
| Journal Title: | Breast Cancer Research |
| Volume: | 3 |
| Issue: | 6 |
| ISSN: | 1465-5411 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2001-10-01 |
| Start Page: | 361 |
| End Page: | 364 |
| Language: | English |
| DOI: | 10.1186/bcr323 |
| PUBMED: | 11737886 |
| PROVIDER: | scopus |
| PMCID: | PMC138701 |
| DOI/URL: | |
| Notes: | Export Date: 21 May 2015 -- Source: Scopus |
