Predictive factors for late genitourinary and gastrointestinal toxicity in patients with prostate cancer treated with adjuvant or salvage radiotherapy Journal Article
| Authors: | Feng, M.; Hanlon, A. L.; Pisansky, T. M.; Kuban, D.; Catton, C. N.; Michalski, J. M.; Zelefsky, M. J.; Kupelian, P. A.; Pollack, A.; Kestin, L. L.; Valicenti, R. K.; DeWeese, T. L.; Sandler, H. M. |
| Article Title: | Predictive factors for late genitourinary and gastrointestinal toxicity in patients with prostate cancer treated with adjuvant or salvage radiotherapy |
| Abstract: | Purpose: To determine the rate and magnitude of late genitourinary (GU) and gastrointestinal (GI) toxicities after salvage or adjuvant radiotherapy (RT) for prostate cancer, and to determine predictive factors for these toxicities. Methods and Materials: A large multi-institutional database that included 959 men who received postoperative RT after radical prostatectomy (RP) was analyzed: 19% received adjuvant RT, 81% received salvage RT, 78% were treated to the prostate bed only, and 22% received radiation to the pelvis. Results: The median follow-up time was 55 months. At 5 years, 10% of patients had Grade 2 late GU toxicity and 1% had Grade 3 late GU toxicity, while 4% of patients had Grade 2 late GI toxicity and 0.4% had Grade 3 late GI toxicity. Multivariate analysis demonstrated that adjuvant RT (p = 0.03), androgen deprivation (p < 0.0001), and prostate bed-only RT (p = 0.007) predicted for Grade 2 or higher late GU toxicity. For GI toxicity, although adjuvant RT was significant in the univariate analysis, no significant factors were found in the multivariate analysis. Conclusions: Overall, the number of high-grade toxicities for postoperative RT was low. Therefore, adjuvant and salvage RT can safely be used in the appropriate settings. © 2007 Elsevier Inc. All rights reserved. |
| Keywords: | adult; aged; middle aged; major clinical study; androgen; postoperative period; salvage therapy; gastrointestinal hemorrhage; adjuvant therapy; cancer patient; cancer radiotherapy; radiotherapy, adjuvant; follow up; follow-up studies; pelvis; radiation; radiotherapy dosage; data base; oncology; hematuria; prostate cancer; prostatic neoplasms; gastrointestinal toxicity; prostatectomy; urinary frequency; multivariate analysis; toxicity; cystitis; urogenital tract disease; univariate analysis; analysis of variance; salvage; biomedical engineering; bladder disease; gastrointestinal diseases; adjuvant; incontinence; urethra stricture; radiation damage; health risks; proctitis; medical problems; male urogenital diseases; salvaging; gastrointestinal (gi) toxicities |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 68 |
| Issue: | 5 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2007-08-01 |
| Start Page: | 1417 |
| End Page: | 1423 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2007.01.049 |
| PUBMED: | 17418972 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 32" - "Export Date: 17 November 2011" - "CODEN: IOBPD" - "Source: Scopus" |
