Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity Journal Article

   


Authors: Harmsen, S.; Bedics, M. A.; Wall, M. A.; Huang, R.; Detty, M. R.; Kircher, M. F.
Article Title: Rational design of a chalcogenopyrylium-based surface-enhanced resonance Raman scattering nanoprobe with attomolar sensitivity
Abstract: High sensitivity and specificity are two desirable features in biomedical imaging. Raman imaging has surfaced as a promising optical modality that offers both. Here we report the design and synthesis of a group of near-infrared absorbing 2-thienyl-substituted chalcogenopyrylium dyes tailored to have high affinity for gold. When adsorbed onto gold nanoparticles, these dyes produce biocompatible SERRS nanoprobes with attomolar limits of detection amenable to ultrasensitive in vivo multiplexed tumour and disease marker detection. © 2015 Macmillan Publishers Limited. All rights reserved.
Keywords: controlled study; unclassified drug; cancer localization; nonhuman; disease marker; cancer diagnosis; binding affinity; sensitivity analysis; animal cell; mouse; animal tissue; animal experiment; animal model; in vivo study; drug structure; in vitro study; tumor xenograft; drug design; drug synthesis; cetuximab; drug accumulation; drug distribution; malignant neoplastic disease; adsorption; biocompatibility; dye; epidermal growth factor receptor antibody; drug stability; particle size; design; resonance; drug solubility; transmission electron microscopy; gold; absorption; thiophene derivative; limit of detection; surface property; sorption; raman spectroscopy; raman spectrometry; gold nanoparticle; female; article; nanoprobe; 4 (3 (2,6 dithiophen 2 yl 4h thiopyran 4 ylidene)prop 1 enyl) (2,6 dithiophen 2 yl)thiopyrylium hexafluorophosphate; 4 [3 (2,6 diphenyl 4h selenopyran 4 ylidene)prop 1 enyl] 2,6 diphenylselenopyrylium; 4 [3 (2,6 diphenyl 4h thiopyran 4 ylidene)prop 1 enyl] 2,6 diphenylselenopyrylium hexafluorophosphate; 4 [3 (2,6 dithiophen 2 yl 4h thiopyran 4 ylidene)prop 1 enyl] 2,6 diphenylselenophyrylium; 4 [3 (2,6 dithiophen 2 yl 4h thiopyran 4 ylidene)prop 1 enyl] 2,6 diphenylthiopyrylium hexafluorophosphate; counterion; cyanine dye; ir 792; optical method
Journal Title: Nature Communications
Volume: 6
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2015-03-24
Start Page: 6570
Language: English
DOI: 10.1038/ncomms7570
PROVIDER: scopus
PMCID: PMC4372816
PUBMED: 25800697
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84925356712&partnerID=40&md5=e66b10b6a38983c22ec6d4b4196cc14c
Notes: Export Date: 4 May 2015 -- Source: Scopus
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MSK Authors
  1. Ruimin Huang
    30 Huang
  2. Moritz Florian Kircher
    55 Kircher
  3. Stefan Harmsen
    17 Harmsen
  4. Matthew Wall
    10 Wall
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