Esophageal and esophagogastric junction cancers, version 1.2015 Journal Article


Authors: Ajani, J. A.; D'Amico, T. A.; Almhanna, K.; Bentrem, D. J.; Besh, S.; Chao, J.; Das, P.; Denlinger, C.; Fanta, P.; Fuchs, C. S.; Gerdes, H.; Glasgow, R. E.; Hayman, J. A.; Hochwald, S.; Hofstetter, W. L.; Ilson, D. H.; Jaroszewski, D.; Jasperson, K.; Keswani, R. N.; Kleinberg, L. R.; Korn, W. M.; Leong, S.; Lockhart, A. C.; Mulcahy, M. F.; Orringer, M. B.; Posey, J. A.; Poultsides, G. A.; Sasson, A. R.; Scott, W. J.; Strong, V. E.; Varghese, T. K.; Washington, M. K.; Willett, C. G.; Wright, C. D.; Zelman, D.; McMillian, N.; Sundar, H.
Article Title: Esophageal and esophagogastric junction cancers, version 1.2015
Abstract: Esophageal cancer is the sixth most common cause of cancer deaths worldwide. Adenocarcinoma is more common in North America and Western European countries, originating mostly in the lower third of the esophagus, which often involves the esophagogastric junction (EGJ). Recent randomized trials have shown that the addition of preoperative chemoradiation or perioperative chemotherapy to surgery significantly improves survival in patients with resectable cancer. Targeted therapies with trastuzumab and ramucirumab have produced encouraging results in the treatment of advanced or metastatic EGJ adenocarcinomas. Multidisciplinary team management is essential for patients with esophageal and EGJ cancers. This portion of the NCCN Guidelines for Esophageal and EGJ Cancers discusses management of locally advanced adenocarcinoma of the esophagus and EGJ. © National Comprehensive Cancer Network, Inc.
Keywords: cancer chemotherapy; cancer surgery; review; cancer recurrence; advanced cancer; multimodality cancer therapy; cancer patient; cancer radiotherapy; postoperative care; preoperative care; cancer staging; follow up; antineoplastic agent; gene overexpression; metastasis; epidermal growth factor receptor 2; practice guideline; cancer mortality; cause of death; stomach cancer; perioperative period; esophagus cancer; chemoradiotherapy; lower esophagus sphincter; oncogene neu; molecularly targeted therapy; esophagogastric junction cancer; human
Journal Title: Journal of the National Comprehensive Cancer Network
Volume: 13
Issue: 2
ISSN: 1540-1405
Publisher: Harborside Press  
Date Published: 2015-02-01
Start Page: 194
End Page: 227
Language: English
PROVIDER: scopus
PUBMED: 25691612
DOI/URL:
Notes: Export Date: 2 April 2015 -- Source: Scopus
MSK Authors
  1. Hans Gerdes
    132 Gerdes
  2. Vivian Strong
    148 Strong
  3. David H Ilson
    280 Ilson
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