Evidence-based approach to the treatment of esophagogastric junction tumors Review
| Authors: | Schlottmann, F.; Casas, M. A.; Molena, D. |
| Review Title: | Evidence-based approach to the treatment of esophagogastric junction tumors |
| Abstract: | The incidence of esophagogastric junction (EGJ) adenocarcinoma is increasing in developed nations due to the rising prevalence of obesity and gastroesophageal reflux disease. Due to the peculiar location in a histological transition zone between the esophagus and the stomach, the management of EGJ tumors is controversial. Two main surgical approaches exist: total gastrectomy with distal esophagectomy or esophagectomy by either transhiatal or transthoracic approach. These operations differ significantly in the extent of lymphadenectomy. In addition, patients with locally advanced disease can receive either preoperative chemoradiation or perioperative chemotherapy. This evidence-based review analyzes current evidence regarding the management of EGJ tumors in order to help defining the best surgical and systemic treatment of these patients.& nbsp;(c) The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Keywords: | chemotherapy; adenocarcinoma; gastrectomy; perioperative chemotherapy; chemoradiation; esophagectomy; esophageal cancer; esophageal; surgical-treatment; gastroesophageal junction; neoadjuvant chemoradiation; gastric cardia; plus chemotherapy; esophagogastric junction tumors; siewert type-ii; transhiatal resection |
| Journal Title: | World Journal of Clinical Oncology |
| Volume: | 13 |
| Issue: | 3 |
| ISSN: | 2218-4333 |
| Publisher: | Baishideng Publishing Group Inc |
| Date Published: | 2022-03-24 |
| Start Page: | 159 |
| End Page: | 167 |
| Language: | English |
| ACCESSION: | WOS:000787205300001 |
| DOI: | 10.5306/wjco.v13.i3.159 |
| PROVIDER: | wos |
| PMCID: | PMC8966513 |
| PUBMED: | 35433293 |
| Notes: | Review -- Source: Wos |
