Association between morphologic CT imaging traits and prognostically relevant gene signatures in women with high-grade serous ovarian cancer: A hypothesis-generating study Journal Article


Authors: Vargas, H. A.; Miccò, M; Hong, S. I.; Goldman, D. A.; Dao, F.; Weigelt, B.; Soslow, R. A.; Hricak, H.; Levine, D. A.; Sala, E.
Article Title: Association between morphologic CT imaging traits and prognostically relevant gene signatures in women with high-grade serous ovarian cancer: A hypothesis-generating study
Abstract: Purpose: To investigate associations among imaging traits observed on computed tomographic (CT) images, Classification of Ovarian Cancer (CLOVAR) gene signatures, and survival in women with high-grade serous ovarian cancer (HGSOC). Materials and Methods: The institutional review board approved this HIPAA-compliant retrospective study of CT images obtained before cytoreductive surgery in 46 women with HGSOC, whose tumors were subjected to molecular analysis performed by the Cancer Genome Atlas Research Network. Two readers independently evaluated the CT features of the primary ovarian mass and sites of metastatic spread if present, including size, outline, and texture. Fisher exact test was used to examine the relationship between imaging traits and CLOVAR subtypes (CLOVAR differentiated, immunoreactive, mesenchymal, and proliferative). Kaplan-Meier and Cox proportional hazards regression survival analyses were performed. Results: The presence of mesenteric infiltration and diffuse peritoneal involvement by tumor at CT were significantly associated with CLOVAR subtype (P = .002-.004 for reader 1 and P = .005-.012 for reader 2). Mesenteric infiltration at CT was associated with CLOVAR mesenchymal subtype. Patients with mesenteric infiltration had shorter median progression-free survival than patients without mesenteric involvement (14.7 months vs 25.6 months according to both readers; P = .019 for reader 1 and .015 for reader 2) and overall survival (49.0 vs 58.2 months; P = .014 [reader 1] and 50.0 vs 59.1 months; P = .015 [reader 2]). No other imaging features were significantly associated with CLOVAR subtype or survival. Conclusion: Specific CT imaging traits were associated with the CLOVAR subtypes and survival in patients with HGSOC. © RSNA, 2014.
Journal Title: Radiology
Volume: 274
Issue: 3
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 2015-03-01
Start Page: 742
End Page: 751
Language: English
DOI: 10.1148/radiol.14141477
PROVIDER: scopus
PUBMED: 25383459
PMCID: PMC4455661
DOI/URL:
Notes: Export Date: 2 April 2015 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Evis Sala
    96 Sala
  2. Douglas A Levine
    356 Levine
  3. Robert Soslow
    650 Soslow
  4. Hedvig Hricak
    335 Hricak
  5. Fanny Dao
    56 Dao
  6. Debra Alyssa Goldman
    99 Goldman
  7. Britta Weigelt
    262 Weigelt
  8. Maura Micco
    10 Micco
  9. Seong Im   Hong
    1 Hong