Extracapsular extension on MRI indicates a more aggressive cell cycle progression genotype of prostate cancer Journal Article
| Authors: | Wibmer, A. G.; Robertson, N. L.; Hricak, H.; Zheng, J.; Capanu, M.; Stone, S.; Ehdaie, B.; Brawer, M. K.; Vargas, H. A. |
| Article Title: | Extracapsular extension on MRI indicates a more aggressive cell cycle progression genotype of prostate cancer |
| Abstract: | Purpose: To explore associations between magnetic resonance imaging (MRI) features of prostate cancer and expression levels of cell cycle genes, as assessed by the Prolaris® test. Materials and methods: Retrospective analysis of 118 PCa patients with genetic testing of biopsy specimen and prostate MRI from 08/2013 to 11/2015. Associations between the cell cycle risk (CCR) score and MRI features [i.e., PI-RADSv2 score, extracapsular extension (ECE), quantitative metrics] were analyzed with Fisher’s exact test, nonparametric tests, and Spearman’s correlation coefficient. In 41 patients (34.7%), test results were compared to unfavorable features on prostatectomy specimen (i.e., Gleason group ≥ 3, ECE, lymph node metastases). Results: Fifty-four (45.8%), 60 (50.8%), and 4 (3.4%) patients had low-, intermediate-, and high-risk cancers according to American Urological Association scoring system. Patients with ECE on MRI had significantly higher mean CCR scores (reader 1: 3.9 vs. 3.2, p = 0.015; reader 2: 3.6 vs. 3.2, p = 0.045). PI-RADSv2 scores and quantitative MRI features were not associated with CCR scores. In the prostatectomy subset, ECE on MRI (p = < 0.001–0.001) and CCR scores (p = 0.049) were significantly associated with unfavorable histopathologic features. Conclusion: The phenotypic trait of ECE on MRI indicates a more aggressive genotype of prostate cancer. © 2019, Springer Science+Business Media, LLC, part of Springer Nature. |
| Keywords: | magnetic resonance imaging; risk assessment; prostate cancer; radiogenomics; cell cycle progression gene expression |
| Journal Title: | Abdominal Radiology |
| Volume: | 44 |
| Issue: | 8 |
| ISSN: | 2366-004X |
| Publisher: | Springer |
| Date Published: | 2019-08-01 |
| Start Page: | 2864 |
| End Page: | 2873 |
| Language: | English |
| DOI: | 10.1007/s00261-019-02023-1 |
| PUBMED: | 31030245 |
| PROVIDER: | scopus |
| PMCID: | PMC7446140 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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