Updated prostate imaging reporting and data system (PIRADS v2) recommendations for the detection of clinically significant prostate cancer using multiparametric MRI: Critical evaluation using whole-mount pathology as standard of reference Journal Article


Authors: Vargas, H. A.; Hötker, A. M.; Goldman, D. A.; Moskowitz, C. S.; Gondo, T.; Matsumoto, K.; Ehdaie, B.; Woo, S.; Fine, S. W.; Reuter, V. E.; Sala, E.; Hricak, H.
Article Title: Updated prostate imaging reporting and data system (PIRADS v2) recommendations for the detection of clinically significant prostate cancer using multiparametric MRI: Critical evaluation using whole-mount pathology as standard of reference
Abstract: To evaluate the recommendations for multiparametric prostate MRI (mp-MRI) interpretation introduced in the recently updated Prostate Imaging Reporting and Data System version 2 (PI-RADSv2), and investigate the impact of pathologic tumour volume on prostate cancer (PCa) detectability on mpMRI. This was an institutional review board (IRB)-approved, retrospective study of 150 PCa patients who underwent mp-MRI before prostatectomy; 169 tumours a parts per thousand yen0.5-mL (any Gleason Score [GS]) and 37 tumours < 0.5-mL (GS a parts per thousand yen4+3) identified on whole-mount pathology maps were located on mp-MRI consisting of T2-weighted imaging (T2WI), diffusion-weighted (DW)-MRI, and dynamic contrast-enhanced (DCE)-MRI. Corresponding PI-RADSv2 scores were assigned on each sequence and combined as recommended by PI-RADSv2. We calculated the proportion of PCa foci on whole-mount pathology correctly identified with PI-RADSv2 (dichotomized scores 1-3 vs. 4-5), stratified by pathologic tumour volume. PI-RADSv2 allowed correct identification of 118/125 (94 %; 95 %CI: 90-99 %) peripheral zone (PZ) and 42/44 (95 %; 95 %CI: 89-100 %) transition zone (TZ) tumours a parts per thousand yen0.5 mL, but only 7/27 (26 %; 95 %CI: 10-42 %) PZ and 2/10 (20 %; 95 %CI: 0-52 %) TZ tumours with a GS a parts per thousand yen4+3, but < 0.5 mL. DCE-MRI aided detection of 4/125 PZ tumours a parts per thousand yen0.5 mL and 0/27 PZ tumours < 0.5 mL. PI-RADSv2 correctly identified 94-95 % of PCa foci a parts per thousand yen0.5 mL, but was limited for the assessment of GS a parts per thousand yen4+3 tumours a parts per thousand currency sign0.5 mL. DCE-MRI offered limited added value to T2WI+DW-MRI. aEuro cent PI-RADSv2 correctly identified 95 % of PCa foci a parts per thousand yen0.5 mL aEuro cent PI-RADSv2 was limited for the assessment of GS a parts per thousand yen4+3 tumours a parts per thousand currency sign0.5 mL aEuro cent DCE-MRI offered limited added value to T2WI+DW-MRI.
Keywords: diffusion; prostate cancer; mri; dce; pi-rads
Journal Title: European Radiology
Volume: 26
Issue: 6
ISSN: 0938-7994
Publisher: Springer  
Date Published: 2016-06-01
Start Page: 1606
End Page: 1612
Language: English
ACCESSION: WOS:000376100100011
DOI: 10.1007/s00330-015-4015-6
PROVIDER: wos
PMCID: PMC4803633
PUBMED: 26396111
Notes: Article -- Source: Wos
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Evis Sala
    113 Sala
  2. Chaya S. Moskowitz
    278 Moskowitz
  3. Behfar Ehdaie
    173 Ehdaie
  4. Hedvig Hricak
    419 Hricak
  5. Samson W Fine
    462 Fine
  6. Victor Reuter
    1228 Reuter
  7. Debra Alyssa Goldman
    158 Goldman
  8. Tatsuo Gondo
    8 Gondo
  9. Andreas Markus Hoetker
    22 Hoetker
  10. Sungmin Woo
    62 Woo