Updated prostate imaging reporting and data system (PIRADS v2) recommendations for the detection of clinically significant prostate cancer using multiparametric MRI: Critical evaluation using whole-mount pathology as standard of reference Journal Article


Authors: Vargas, H. A.; Hötker, A. M.; Goldman, D. A.; Moskowitz, C. S.; Gondo, T.; Matsumoto, K.; Ehdaie, B.; Woo, S.; Fine, S. W.; Reuter, V. E.; Sala, E.; Hricak, H.
Article Title: Updated prostate imaging reporting and data system (PIRADS v2) recommendations for the detection of clinically significant prostate cancer using multiparametric MRI: Critical evaluation using whole-mount pathology as standard of reference
Abstract: To evaluate the recommendations for multiparametric prostate MRI (mp-MRI) interpretation introduced in the recently updated Prostate Imaging Reporting and Data System version 2 (PI-RADSv2), and investigate the impact of pathologic tumour volume on prostate cancer (PCa) detectability on mpMRI. This was an institutional review board (IRB)-approved, retrospective study of 150 PCa patients who underwent mp-MRI before prostatectomy; 169 tumours a parts per thousand yen0.5-mL (any Gleason Score [GS]) and 37 tumours < 0.5-mL (GS a parts per thousand yen4+3) identified on whole-mount pathology maps were located on mp-MRI consisting of T2-weighted imaging (T2WI), diffusion-weighted (DW)-MRI, and dynamic contrast-enhanced (DCE)-MRI. Corresponding PI-RADSv2 scores were assigned on each sequence and combined as recommended by PI-RADSv2. We calculated the proportion of PCa foci on whole-mount pathology correctly identified with PI-RADSv2 (dichotomized scores 1-3 vs. 4-5), stratified by pathologic tumour volume. PI-RADSv2 allowed correct identification of 118/125 (94 %; 95 %CI: 90-99 %) peripheral zone (PZ) and 42/44 (95 %; 95 %CI: 89-100 %) transition zone (TZ) tumours a parts per thousand yen0.5 mL, but only 7/27 (26 %; 95 %CI: 10-42 %) PZ and 2/10 (20 %; 95 %CI: 0-52 %) TZ tumours with a GS a parts per thousand yen4+3, but < 0.5 mL. DCE-MRI aided detection of 4/125 PZ tumours a parts per thousand yen0.5 mL and 0/27 PZ tumours < 0.5 mL. PI-RADSv2 correctly identified 94-95 % of PCa foci a parts per thousand yen0.5 mL, but was limited for the assessment of GS a parts per thousand yen4+3 tumours a parts per thousand currency sign0.5 mL. DCE-MRI offered limited added value to T2WI+DW-MRI. aEuro cent PI-RADSv2 correctly identified 95 % of PCa foci a parts per thousand yen0.5 mL aEuro cent PI-RADSv2 was limited for the assessment of GS a parts per thousand yen4+3 tumours a parts per thousand currency sign0.5 mL aEuro cent DCE-MRI offered limited added value to T2WI+DW-MRI.
Keywords: diffusion; prostate cancer; mri; dce; pi-rads
Journal Title: European Radiology
Volume: 26
Issue: 6
ISSN: 0938-7994
Publisher: Springer  
Date Published: 2016-06-01
Start Page: 1606
End Page: 1612
Language: English
ACCESSION: WOS:000376100100011
DOI: 10.1007/s00330-015-4015-6
PROVIDER: wos
PMCID: PMC4803633
PUBMED: 26396111
Notes: Article -- Source: Wos
Altmetric Score
MSK Authors
  1. Evis Sala
    95 Sala
  2. Chaya S. Moskowitz
    173 Moskowitz
  3. Behfar Ehdaie
    73 Ehdaie
  4. Hedvig Hricak
    330 Hricak
  5. Samson W Fine
    316 Fine
  6. Victor Reuter
    913 Reuter
  7. Debra Alyssa Goldman
    94 Goldman
  8. Tatsuo Gondo
    8 Gondo
  9. Andreas Markus Hoetker
    21 Hoetker