Incremental value of diffusion weighted and dynamic contrast enhanced MRI in the detection of locally recurrent prostate cancer after radiation treatment: Preliminary results Journal Article


Authors: Akin, O.; Gultekin, D. H.; Vargas, H. A.; Zheng, J.; Moskowitz, C.; Pei, X.; Sperling, D.; Schwartz, L. H.; Hricak, H.; Zelefsky, M. J.
Article Title: Incremental value of diffusion weighted and dynamic contrast enhanced MRI in the detection of locally recurrent prostate cancer after radiation treatment: Preliminary results
Abstract: Objectives: To assess the incremental value of diffusion-weighted (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) to T2-weighted MRI (T2WI) in detecting locally recurrent prostate cancer after radiotherapy. Methods: Twenty-four patients (median age, 70 years) with a history of radiotherapy-treated prostate cancer underwent multi-parametric MRI (MP-MRI) and transrectal prostate biopsy. Two readers independently scored the likelihood of cancer on a 1-5 scale, using T2WI alone and then adding DW-MRI and DCE-MRI. Areas under receiver operating characteristic curves (AUCs) were estimated at the patient and prostate-side levels. The apparent diffusion coefficient (ADC) from DW-MRI and the Ktrans, kep, ve, AUGC90 and AUGC180 from DCE-MRI were recorded. Results: Biopsy was positive in 16/24 (67%) and negative in 8/24 (33%) patients. AUCs for readers 1 and 2 increased from 0.64 and 0.53 to 0.95 and 0.86 with MP-MRI, at the patient level, and from 0.73 and 0.66 to 0.90 and 0.79 with MP-MRI, at the prostate-side level (p values < 0.05). Biopsy-positive and biopsy-negative prostate sides differed significantly in median ADC [1.44 vs. 1.68 (×10-3 mm 2/s)], median Ktrans [1.07 vs. 0.34 (1/min)], and k ep [2.06 vs 1.0 (1/min)] (p values < 0.05). Conclusions: MP-MRI was significantly more accurate than T2WI alone in detecting locally recurrent prostate cancer after radiotherapy. © 2011 European Society of Radiology.
Keywords: prostate; dynamic contrast-enhanced mri; mri; functional imaging; diffusion-weighted mri
Journal Title: European Radiology
Volume: 21
Issue: 9
ISSN: 0938-7994
Publisher: Springer  
Date Published: 2011-09-01
Start Page: 1970
End Page: 1978
Language: English
DOI: 10.1007/s00330-011-2130-6
PROVIDER: scopus
PUBMED: 21533634
PMCID: PMC3730825
DOI/URL:
Notes: --- - "Export Date: 3 October 2011" - "CODEN: EURAE" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Junting Zheng
    133 Zheng
  2. Michael J Zelefsky
    624 Zelefsky
  3. Chaya S. Moskowitz
    173 Moskowitz
  4. Hedvig Hricak
    333 Hricak
  5. Oguz Akin
    179 Akin
  6. Xin Pei
    98 Pei