Incremental value of diffusion weighted and dynamic contrast enhanced MRI in the detection of locally recurrent prostate cancer after radiation treatment: Preliminary results Journal Article
| Authors: | Akin, O.; Gultekin, D. H.; Vargas, H. A.; Zheng, J.; Moskowitz, C.; Pei, X.; Sperling, D.; Schwartz, L. H.; Hricak, H.; Zelefsky, M. J. |
| Article Title: | Incremental value of diffusion weighted and dynamic contrast enhanced MRI in the detection of locally recurrent prostate cancer after radiation treatment: Preliminary results |
| Abstract: | Objectives: To assess the incremental value of diffusion-weighted (DW-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) to T2-weighted MRI (T2WI) in detecting locally recurrent prostate cancer after radiotherapy. Methods: Twenty-four patients (median age, 70 years) with a history of radiotherapy-treated prostate cancer underwent multi-parametric MRI (MP-MRI) and transrectal prostate biopsy. Two readers independently scored the likelihood of cancer on a 1-5 scale, using T2WI alone and then adding DW-MRI and DCE-MRI. Areas under receiver operating characteristic curves (AUCs) were estimated at the patient and prostate-side levels. The apparent diffusion coefficient (ADC) from DW-MRI and the Ktrans, kep, ve, AUGC90 and AUGC180 from DCE-MRI were recorded. Results: Biopsy was positive in 16/24 (67%) and negative in 8/24 (33%) patients. AUCs for readers 1 and 2 increased from 0.64 and 0.53 to 0.95 and 0.86 with MP-MRI, at the patient level, and from 0.73 and 0.66 to 0.90 and 0.79 with MP-MRI, at the prostate-side level (p values < 0.05). Biopsy-positive and biopsy-negative prostate sides differed significantly in median ADC [1.44 vs. 1.68 (×10-3 mm 2/s)], median Ktrans [1.07 vs. 0.34 (1/min)], and k ep [2.06 vs 1.0 (1/min)] (p values < 0.05). Conclusions: MP-MRI was significantly more accurate than T2WI alone in detecting locally recurrent prostate cancer after radiotherapy. © 2011 European Society of Radiology. |
| Keywords: | prostate; dynamic contrast-enhanced mri; mri; functional imaging; diffusion-weighted mri |
| Journal Title: | European Radiology |
| Volume: | 21 |
| Issue: | 9 |
| ISSN: | 0938-7994 |
| Publisher: | Springer |
| Date Published: | 2011-09-01 |
| Start Page: | 1970 |
| End Page: | 1978 |
| Language: | English |
| DOI: | 10.1007/s00330-011-2130-6 |
| PROVIDER: | scopus |
| PUBMED: | 21533634 |
| PMCID: | PMC3730825 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 October 2011" - "CODEN: EURAE" - "Source: Scopus" |
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