Multiparametric MRI in the assessment of response of rectal cancer to neoadjuvant chemoradiotherapy: A comparison of morphological, volumetric and functional MRI parameters Journal Article

   

Authors:	Hötker, A. M.; Tarlinton, L.; Mazaheri, Y.; Woo, K. M.; Gönen, M.; Saltz, L. B.; Goodman, K. A.; Garcia-Aguilar, J.; Gollub, M. J.
Article Title:	Multiparametric MRI in the assessment of response of rectal cancer to neoadjuvant chemoradiotherapy: A comparison of morphological, volumetric and functional MRI parameters
Abstract:	Purpose: To compare morphological and functional MRI metrics and determine which ones perform best in assessing response to neoadjuvant chemoradiotherapy (CRT) in rectal cancer. Materials and methods: This retrospective study included 24 uniformly-treated patients with biopsy-proven rectal adenocarcinoma who underwent MRI, including diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) sequences, before and after completion of CRT. On all MRI exams, two experienced readers independently measured longest and perpendicular tumour diameters, tumour volume, tumour regression grade (TRG) and tumour signal intensity ratio on T2-weighted imaging, as well as tumour volume and apparent diffusion coefficient on DW-MRI and tumour volume and transfer constant Ktrans on DCE-MRI. These metrics were correlated with histopathological percent tumour regression in the resected specimen (%TR). Inter-reader agreement was assessed using the concordance correlation coefficient (CCC). Results: For both readers, post-treatment DW-MRI and DCE-MRI volumetric tumour assessments were significantly associated with %TR; DCE-MRI volumetry showed better inter-reader agreement (CCC=0.700) than DW-MRI volumetry (CCC=0.292). For one reader, mrTRG, post-treatment T2 tumour volumetry and assessments of volume change made with T2, DW-MRI and DCE-MRI were also significantly associated with %TR. Conclusion: Tumour volumetry on post-treatment DCE-MRI and DW-MRI correlated well with %TR, with DCE-MRI volumetry demonstrating better inter-reader agreement. Key Points: • Volumetry on post-treatment DCE-/DW-MRI sequences correlated well with histopathological tumour regression. • DCE-MRI volumetry demonstrated good inter-reader agreement. • Inter-reader agreement was higher for DCE-MRI volumetry than for DW-MRI volumetry. • DCE-MRI volumetry merits further investigation as a metric for evaluating treatment response. © 2016, European Society of Radiology.
Keywords:	magnetic resonance imaging; dynamic contrast-enhanced mri; rectal cancer; neoadjuvant treatment; diffusion mri
Journal Title:	European Radiology
Volume:	26
Issue:	12
ISSN:	0938-7994
Publisher:	Springer
Date Published:	2016-12-01
Start Page:	4303
End Page:	4312
Language:	English
DOI:	10.1007/s00330-016-4283-9
PROVIDER:	scopus
PUBMED:	26945761
PMCID:	PMC5203699
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960112323&partnerID=40&md5=852ead3b148760a3568546664698ace0
Notes:	Article -- Export Date: 6 December 2016 -- Source: Scopus

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