Radiogenomics of high-grade serous ovarian cancer: Multireader multi-institutional study from the Cancer Genome Atlas Ovarian Cancer Imaging Research Group Journal Article


Authors: Vargas, H. A.; Huang, E. P.; Lakhman, Y.; Ippolito, J. E.; Bhosale, P.; Mellnick, V.; Shinagare, A. B.; Anello, M.; Kirby, J.; Fevrier-Sullivan, B.; Freymann, J.; Jaffe, C. C.; Sala, E.
Article Title: Radiogenomics of high-grade serous ovarian cancer: Multireader multi-institutional study from the Cancer Genome Atlas Ovarian Cancer Imaging Research Group
Abstract: Purpose: To evaluate interradiologist agreement on assessments of computed tomography (CT) imaging features of highgrade serous ovarian cancer (HGSOC), to assess their associations with time-to-disease progression (TTP) and HGSOC transcriptomic profiles (Classification of Ovarian Cancer [CLOVAR]), and to develop an imaging-based risk score system to predict TTP and CLOVAR profiles. Materials and Methods: This study was a multireader, multi-institutional, institutional review board-approved, HIPAA-compliant retrospective analysis of 92 patients with HGSOC (median age, 61 years) with abdominopelvic CT before primary cytoreductive surgery available through the Cancer Imaging Archive. Eight radiologists from the Cancer Genome Atlas Ovarian Cancer Imaging Research Group developed and independently recorded the following CT features: characteristics of primary ovarian mass(es), presence of definable mesenteric implants and infiltration, presence of other implants, presence and distribution of peritoneal spread, presence and size of pleural effusions and ascites, lymphadenopathy, and distant metastases. Interobserver agreement for CT features was assessed, as were univariate and multivariate associations with TTP and CLOVAR mesenchymal profile (worst prognosis). Results: Interobserver agreement for some features was strong (eg, α = .78 for pleural effusion and ascites) but was lower for others (eg, α = .08 for intraparenchymal splenic metastases). Presence of peritoneal disease in the right upper quadrant (P = .0003), supradiaphragmatic lymphadenopathy (P = .0004), more peritoneal disease sites (P = .0006), and nonvisualization of a discrete ovarian mass (P = .0037) were associated with shorter TTP. More peritoneal disease sites (P = .0025) and presence of pouch of Douglas implants (P = .0045) were associated with CLOVAR mesenchymal profile. Combinations of imaging features contained predictive signal for TTP (concordance index = 0.658; P = .0006) and CLOVAR profile (mean squared deviation = 1.776; P = .0043). Conclusion: These results provide some evidence of the clinical and biologic validity of these image features. Interobserver agreement is strong for some features, but could be improved for others. © RSNA, 2017.
Keywords: adult; cancer survival; controlled study; human tissue; middle aged; retrospective studies; gene mutation; human cell; major clinical study; genetics; clinical trial; ascites; cancer growth; cancer staging; cancer grading; cell proliferation; cytoreductive surgery; ovarian neoplasms; computer assisted tomography; ovary cancer; gene expression profiling; tumor volume; prevalence; tomography, x-ray computed; diagnostic imaging; immunoreactivity; retrospective study; cancer research; distant metastasis; cancer genetics; survival time; liver metastasis; lung metastasis; multicenter study; genomics; mesenchymal stem cell; pleura effusion; platinum complex; gene dosage; cancer classification; lymphadenopathy; image reconstruction; pleura metastasis; peritoneal disease; procedures; cancer prognosis; spleen metastasis; retroperitoneal adenopathy; humans; human; female; priority journal; article; radiogenomics; x-ray computed tomography; inguinal adenopathy; positron emission tomography-computed tomography; high grade serous ovarian cancer; gastro hepatic adenopathy; pelvic adenopathy; retrocrural adenopathy; supradiaphragmatic adenopathy; thoracic adenopathy; time-to-disease progression
Journal Title: Radiology
Volume: 285
Issue: 2
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 2017-11-01
Start Page: 482
End Page: 492
Language: English
DOI: 10.1148/radiol.2017161870
PUBMED: 28641043
PROVIDER: scopus
PMCID: PMC5673051
DOI/URL:
Notes: Article -- Export Date: 4 December 2017 -- Source: Scopus
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MSK Authors
  1. Yuliya Lakhman
    34 Lakhman
  2. Evis Sala
    95 Sala