Synthesis of 2'-deoxy-2-fluoro-1-β-D-arabinofuranosyl uracil derivatives: A method suitable for preparation of [(18)F]-labeled nucleosides Journal Article
| Authors: | Alauddin, M. M.; Conti, P. S.; Fissekis, J. D.; Watanabe, K. A. |
| Article Title: | Synthesis of 2'-deoxy-2-fluoro-1-β-D-arabinofuranosyl uracil derivatives: A method suitable for preparation of [(18)F]-labeled nucleosides |
| Abstract: | N-glycosylation of 2,4-bis-O-(trimethylsilyl)-pyrimidine bases with 2-deoxy-2-fluoro-3,5-di-O-benzoyl-1-(Br, OBz)-alpha-D-arabinose derivatives are reported. I-Bromo-arabinose provides high yield and a favorable anomeric ratio (beta/alpha) of pyrimidine nucleoside in either MeCN or CH2Cl-CH2Cl. This method should be suitable for the synthesis of 2'-deoxy-2-[F-18]fluoro-1-beta-D-arabinofuranosyluracil derivatives. |
| Keywords: | antiviral nucleosides; fmau |
| Journal Title: | Synthetic Communications |
| Volume: | 32 |
| Issue: | 11 |
| ISSN: | 0039-7911 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2002-01-01 |
| Start Page: | 1757 |
| End Page: | 1764 |
| Language: | English |
| ACCESSION: | WOS:000176515400021 |
| DOI: | 10.1081/scc-120004272 |
| PROVIDER: | wos |
| Notes: | Article -- Source: Wos |
