Studies directed toward the synthesis of 2'-deoxy-2'-substituted arabino nucleosides Journal Article
| Authors: | Pankiewicz, K. W.; Nawrot, B.; Sochacka, E.; Watanabe, K. A. |
| Article Title: | Studies directed toward the synthesis of 2'-deoxy-2'-substituted arabino nucleosides |
| Abstract: | Synthesis of the C-nucleoside, 5-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-1-methyluracil, isosteric to the potent antiviral and anticancer nucleoside, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-1-methyluracil (2'-fluoro-5-methyl-ara-U or FMAU) was achieved by exploitation of the 4,5'-anhydro-nucleoside. Attempts at application of this ribosyl-to-arabinosyl pyrimidine transformation to 2,5'-anhydrouridine resulted in the formation of 2,2'-anhydro-5-substituted-arabinosyluracil. |
| Keywords: | synthesis; indicators and reagents; arabinonucleosides; arabinonucleoside; dyes, reagents, indicators, markers and buffers; article |
| Journal Title: | Nucleic Acids Symposium Series |
| Issue: | 18 |
| ISSN: | 0261-3166 |
| Publisher: | Oxford University Press |
| Date Published: | 1987-01-01 |
| Start Page: | 257 |
| End Page: | 260 |
| Language: | English |
| PUBMED: | 3697138 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
