Antibiotic prophylaxis in patients receiving hematopoietic stem cell transplant Journal Article
| Author: | Sepkowitz, K. A. |
| Article Title: | Antibiotic prophylaxis in patients receiving hematopoietic stem cell transplant |
| Abstract: | Effective prophylaxis against specific infections has allowed increasingly potent conditioning regimens to be given, thereby prolonging survival in HSCT recipients. The Centers for Disease Control and Prevention, in collaboration with numerous professional societies, has recently published guidelines to codify and advance this approach. Controversy remains in several areas but, curiously, the most intense debate concerns prevention of bacterial infections, the most extensively studied of all of the approaches. Central to this debate are the competing priorities of a potentially ill patient on the one hand vs the long-term consequences of unchecked antibiotic use. The emergence in the 1990s of vancomycin-resistant Enterococcus demonstrated all too vividly how devastating such an end result could be. This article will review the arguments for and against the routine use of antibacterial prophylaxis in HSCT recipients. |
| Keywords: | controlled study; antibiotic agent; review; drug efficacy; cytarabine; stomatitis; cyclophosphamide; practice guideline; hematopoietic stem cell transplantation; drug resistance; antibiotic resistance; drug resistance, bacterial; prophylaxis; ciprofloxacin; graft versus host reaction; sepsis; short survey; bacteremia; graft survival; enterococcus; linezolid; cotrimoxazole; levofloxacin; metronidazole; quinoline derived antiinfective agent; bacterial infection; infection control; antibiotic prophylaxis; bacterial infections; drug use; opportunistic infections; opportunistic infection; streptomycin; aminoglycoside; neomycin; cephalosporin derivative; amoxicillin plus clavulanic acid; imipenem; gram negative infection; penicillin g; tuberculous meningitis; beta lactam; humans; human; priority journal; ramoplanin; polymyxin |
| Journal Title: | Bone Marrow Transplantation |
| Volume: | 29 |
| Issue: | 5 |
| ISSN: | 0268-3369 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2002-03-01 |
| Start Page: | 367 |
| End Page: | 371 |
| Language: | English |
| DOI: | 10.1038/sj.bmt.1703366 |
| PUBMED: | 11919724 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
