New agents for the prevention of opportunistic infections in haematopoietic stem cell transplant recipients Journal Article
| Authors: | Zuccotti, G.; Strasfeld, L.; Weinstock, D. M. |
| Article Title: | New agents for the prevention of opportunistic infections in haematopoietic stem cell transplant recipients |
| Abstract: | Over the past three decades, autologous and allogeneic haematopoietic stem cell transplants (HSCTs) have become effective treatments for a variety of malignant and nonmalignant conditions. Patients who undergo HSCT receive high doses of chemotherapy and/or radiation that induce a prolonged period of profound immunodeficiency, placing them at high risk for infection from a panoply of opportunistic organisms. Although supportive treatment for these patients has markedly improved, 10 - 20% of allogeneic HSCT recipients will ultimately succumb to infection. Joint guidelines to prevent opportunistic infection were released in 2000 by the Centers for Disease Control, the Infectious Diseases Society of America, and the American Society of Blood and Marrow Transplantation; however, treatment decisions for these patients are often based on limited studies or depend on institution-specific transplant protocols and antibiotic resistance patterns. This paper will discuss new agents for preventing bacterial, fungal and viral infections in HSCT recipients. © 2005 Ashley Publications Ltd. |
| Keywords: | clinical trial; review; diarrhea; drug penetration; methotrexate; drug megadose; antineoplastic agent; unindexed drug; drug eruption; infection; gastrointestinal symptom; nausea; myalgia; peripheral neuropathy; stem cell transplant; aciclovir; antifungal agent; hematopoietic stem cell transplantation; in vitro study; high risk patient; abdominal pain; dizziness; drug fever; injection site reaction; drug cost; antiinfective agent; antibiotic resistance; prophylaxis; ciprofloxacin; graft versus host reaction; allogeneic hematopoietic stem cell transplantation; antivirus agent; cidofovir; virus infection; linezolid; vancomycin; immune deficiency; immunocompromised host; drugs, investigational; abnormally high substrate concentration in blood; tacrolimus; dyspepsia; flatulence; levofloxacin; bacterial infection; infection control; fluconazole; foscarnet; ganciclovir; mycosis; cyclosporin; infection risk; aspergillosis; respiratory tract infection; autologous hematopoietic stem cell transplantation; bone marrow toxicity; opportunistic infections; thymocyte antibody; opportunistic infection; itraconazole; moxifloxacin; valganciclovir; recipient; anti-infective agents; amantadine; famciclovir; daptomycin; valaciclovir; gatifloxacin; thrombocytopenic purpura; amphotericin b; mycophenolic acid; optic nerve disease; rimantadine; foscarnet sodium; gemifloxacin |
| Journal Title: | Expert Opinion on Pharmacotherapy |
| Volume: | 6 |
| Issue: | 10 |
| ISSN: | 1465-6566 |
| Publisher: | Informa Healthcare |
| Date Published: | 2005-08-01 |
| Start Page: | 1669 |
| End Page: | 1679 |
| Language: | English |
| DOI: | 10.1517/14656566.6.10.1669 |
| PUBMED: | 16086653 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 24 October 2012" - "CODEN: EOPHF" - "Source: Scopus" |
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