Respiratory syncytial virus infection following hematopoietic stem cell transplantation Journal Article
| Authors: | Small, T. N.; Casson, A.; Malak, S. F.; Boulad, F.; Kiehn, T. E.; Stiles, J.; Ushay, H. M.; Sepkowitz, K. A. |
| Article Title: | Respiratory syncytial virus infection following hematopoietic stem cell transplantation |
| Abstract: | Respiratory syncytial virus, one of the most common causes of respiratory infections in immunocompetent individuals, is frequently spread to recipients of HSCT by family members, other patients, and health care workers. In immunosuppressed individuals, progression from upper respiratory tract disease to pneumonia is common, and usually fatal if left untreated. We performed a retrospective analysis of RSV infections in recipients of autologous or allogeneic transplants. The incidence of RSV following allogeneic or autologous HSCT was 5.7% and 1.5%, respectively. Of the 58 patients with an RSV infection, 16 of 21 patients identified within the first post-transplant month, developed pneumonia. Seventy-two percent of patients received aerosolized ribavirin and/or RSV-IGIV, including 23 of 25 patients diagnosed with RSV pneumonia. In this aggressively treated patient population, three patients died of RSV disease, each following an unrelated HSCT. |
| Keywords: | adolescent; adult; child; controlled study; aged; middle aged; leukemia; retrospective studies; transplantation, homologous; major clinical study; disease course; mortality; methotrexate; anemia; incidence; immunoglobulin; steroid; hematopoietic stem cell transplantation; retrospective study; pneumonia; myelodysplastic syndrome; whole body radiation; lymphoma; graft versus host reaction; cyclosporin a; transplantation, autologous; ribavirin; respiratory tract infection; respiratory syncytial pneumovirus; respiratory syncytial virus infections; allotransplantation; immunosuppressive agent; myeloma; immunosuppression; antiviral agents; immunoglobulins, intravenous; autotransplantation; respiratory tract infections; pneumonia, viral; aerosols; humans; human; male; female; priority journal; article; respiratory syncytial virus(rsv); respiratory syncytial virus antibody |
| Journal Title: | Bone Marrow Transplantation |
| Volume: | 29 |
| Issue: | 4 |
| ISSN: | 0268-3369 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2002-02-01 |
| Start Page: | 321 |
| End Page: | 327 |
| Language: | English |
| DOI: | 10.1038/sj.bmt.1703365 |
| PUBMED: | 11896429 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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