Guidelines for infection prophylaxis, monitoring and therapy in cord blood transplantation Guidelines


Authors: Olson, A. L.; Politikos, I.; Brunstein, C.; Milano, F.; Barker, J.; Hill, J. A.; on behalf of the American Society for Transplantation and Cellular Therapy Cord Blood Special Interest Group
Title: Guidelines for infection prophylaxis, monitoring and therapy in cord blood transplantation
Abstract: As an alternative stem cell source, cord blood (CB) has many advantages. However, delayed engraftment, lack of transferred immunity, and a significant incidence of acute graft-versus-host disease renders CB transplant (CBT) recipients at high risk of infectious complications. This guidance written by CBT and infectious disease experts outlines evidence-based recommendations for the prevention and treatment of opportunistic infections in adult patients undergoing CBT. Topics addressed include bacterial, fungal, viral, pneumocystis jirovcii and toxoplasmosis prophylaxis, suggested PCR monitoring for viruses, therapy for the most commonly encountered infections after CBT. We review key concepts including the recent important role of letermovir in the prevention of CMV reactivation. In instances where there is a paucity of data, practice recommendations are provided, including the duration of antimicrobial prophylaxis. © 2021 The American Society for Transplantation and Cellular Therapy
Keywords: cord; blood transplantation; cbt; infection prophylaxis
Journal Title: Transplantation and Cellular Therapy
Volume: 27
Issue: 5
ISSN: 2666-6367
Publisher: Elsevier Inc.  
Date Published: 2021-05-01
Start Page: 359
End Page: 362
Language: English
DOI: 10.1016/j.jtct.2021.01.024
PROVIDER: scopus
PUBMED: 33965172
DOI/URL:
Notes: Article -- Export Date: 1 June 2021 -- Source: Scopus
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  1. Juliet N Barker
    296 Barker