Guidelines for adult patient selection and conditioning regimens in cord blood transplant recipients with hematologic malignancies and aplastic anemia Guidelines


Authors: Metheny, L.; Politikos, I.; Ballen, K. K.; Rezvani, A. R.; Milano, F.; Barker, J. N.; Brunstein, C. G.; on behalf of the American Society for Transplantation and Cellular Therapy Cord Blood Special Interest Group
Title: Guidelines for adult patient selection and conditioning regimens in cord blood transplant recipients with hematologic malignancies and aplastic anemia
Abstract: For cord blood transplantation (CBT), appropriate patient and conditioning regimen selection is necessary to achieve long-term disease-free survival. This review aims to provide comprehensive guidelines on these issues using evidence from the literature and experience at dedicated CBT centers. Topics include patient and disease characteristics that make CBT a good or poor choice and a review of outcomes in commonly used conditioning regimens in CBT. This is accompanied with recommendations on regimen intensity based on disease, organ function, and patient performance status and age. In addition, the use of antithymocyte globulin in CBT is discussed, as is the choice of conditioning in aplastic anemia patients who have access to acceptable CB units. © 2020 The American Society for Transplantation and Cellular Therapy
Keywords: hematologic malignancies; conditioning regimens; cord blood transplant
Journal Title: Transplantation and Cellular Therapy
Volume: 27
Issue: 4
ISSN: 2666-6367
Publisher: Elsevier Inc.  
Date Published: 2021-04-01
Start Page: 286
End Page: 291
Language: English
DOI: 10.1016/j.jtct.2020.11.008
PROVIDER: scopus
PUBMED: 33836867
DOI/URL:
Notes: Article -- Export Date: 3 May 2021 -- Source: Scopus
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  1. Juliet N Barker
    292 Barker