Guidelines for the prevention and management of graft-versus-host disease after cord blood transplantation Guidelines
| Authors: | Ponce, D. M.; Politikos, I.; Alousi, A.; Carpenter, P. A.; Milano, F.; MacMillan, M. L.; Barker, J. N.; Horwitz, M. E.; on behalf of the American Society for Transplantation Cellular Therapy Cord Blood Special Interest Group |
| Title: | Guidelines for the prevention and management of graft-versus-host disease after cord blood transplantation |
| Abstract: | The incidence of graft-versus-host disease (GVHD) after cord blood (CB) transplantation (CBT) is lower than expected given the marked degree of human leukocyte antigen (HLA)-mismatch of CB grafts. While the exact mechanism that underlies this biology remains unclear, it is hypothesized to be due to the low number of mostly immature T-cells infused as part of the graft1,2, and increased tolerance of CB-derived lymphocytes induced by the state of pregnancy. Nevertheless, acute GVHD (aGVHD) is a significant complication of CBT. In contrast, the incidence of chronic GVHD (cGVHD) following CBT is lower than what is observed following matched related or unrelated donor HSC transplantation (HSCT)3-6. This review outlines the guidelines for the prevention and management of acute and chronic GVHD following CBT. © 2021 The American Society for Transplantation and Cellular Therapy |
| Keywords: | practice guideline; graft-versus-host disease; cord blood transplant |
| Journal Title: | Transplantation and Cellular Therapy |
| Volume: | 27 |
| Issue: | 7 |
| ISSN: | 2666-6375 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2021-07-01 |
| Start Page: | 540 |
| End Page: | 544 |
| Language: | English |
| DOI: | 10.1016/j.jtct.2021.03.012 |
| PUBMED: | 34210500 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 August 2021 -- Source: Scopus |
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