Combined umbilical cord blood and bone marrow from HLA-identical sibling donors for hematopoietic stem cell transplantation in children with hemoglobinopathies Journal Article

  

Authors:	Soni, S.; Boulad, F.; Cowan, M. J.; Scaradavou, A.; Dahake, J.; Edwards, S.; Walters, M. C.
Article Title:	Combined umbilical cord blood and bone marrow from HLA-identical sibling donors for hematopoietic stem cell transplantation in children with hemoglobinopathies
Abstract:	Background: It is well established that umbilical cord blood and bone marrow are biologically different stem cell sources. Patients and Methods: We analyzed the feasibility and outcome of hematopoietic stem cell transplantation (HSCT) in 13 children (median age 5.9 years) with hemoglobinopathies after the co- infusion of cord blood (CB) and bone marrow (BM) from the same human leucocyte antigen (HLA) identical sibling donor. We also compared outcomes of children with co-transplantation to outcomes in children with hemoglobinopathies who had received a BM (n=21) or CB (n=22) transplant alone. Results: Compared to CB transplant (CBT) recipients, the co-transplant group had more rapid neutrophil (17 vs. 25 days, P=0.013) and platelet (29 vs. 48 days, P=0.009) recovery and less transplant related mortality. Patients who received a co-transplant had a lower incidence of ≥grade II acute (0% vs. 26.3%) and chronic (0% vs. 21%) graft versus host disease (GVHD) compared to BM transplant (BMT) recipients (P=0.055 and 0.045, respectively). With a median follow-up of >60 months in each treatment group, the 5-year probability of event free survival (EFS) was 100% in the co-transplant group, 90% after BMT and 86% after CBT (P=0.42). Conclusion: Co-transplantation of CB and BM from HLA-identical sibling donors appears to be a feasible and effective strategy to further optimize outcomes of HSCT for hemoglobinopathies. © 2014 Wiley Periodicals, Inc.
Keywords:	thalassemia; sickle cell disease; bone marrow transplant; hemoglobinopathy; cord blood transplant
Journal Title:	Pediatric Blood and Cancer
Volume:	61
Issue:	9
ISSN:	1545-5009
Publisher:	Wiley Periodicals, Inc
Date Published:	2014-09-01
Start Page:	1690
End Page:	1694
Language:	English
DOI:	10.1002/pbc.25085
PROVIDER:	scopus
PUBMED:	24803091
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84904430620&partnerID=40&md5=8b1acabcbc78807881f9496172247389
Notes:	Export Date: 1 August 2014 -- CODEN: PBCEA -- Source: Scopus

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