Microdissection testicular sperm extraction in men with Sertoli cell-only testicular histology Journal Article

Authors: Berookhim, B. M.; Palermo, G. D.; Zaninovic, N.; Rosenwaks, Z.; Schlegel, P. N.
Article Title: Microdissection testicular sperm extraction in men with Sertoli cell-only testicular histology
Abstract: Objective: To study the outcomes of microdissection testicular sperm extraction (microTESE) among men with pure Sertoli cell-only histology on diagnostic testicular biopsy. Design: Retrospective cohort study. Setting: Tertiary referral center. Patient(s): Six hundred forty patients with pure Sertoli cell-only histology on testicular biopsy who underwent microTESE by a single surgeon. Intervention(s): MicroTESE. Main Outcome Measure(s): Sperm retrieval rates. Result(s): Overall, 44.5% of patients with Sertoli cell only had sperm retrieved with microTESE. No difference was noted in sperm retrieval rates based on testis volume (≥15 mL vs. <15 mL, 35.3% vs. 46.1%, respectively). Patients with ≥15 mL testicular volume and FSH 10-15 mU/mL had the worst prognosis, with a sperm retrieval rate of 6.7%. Conclusion(s): Patients with previous testicular biopsy demonstrating Sertoli cell-only histology can be counseled that they have a reasonable likelihood of sperm retrieval with the contemporary delivery of microTESE. Given this finding, the utility of testicular biopsy before microTESE is further questioned.
Keywords: adult; controlled study; human tissue; human cell; major clinical study; outcome assessment; cohort analysis; medical record review; retrospective study; histology; orchitis; follitropin; male infertility; microdissection; azoospermia; hypogonadotropic hypogonadism; sertoli cell; testis size; cryptorchism; follitropin blood level; klinefelter syndrome; varicocele; testis biopsy; testicular sperm extraction; pregnancy rate; prognosis; human; male; priority journal; article; patient history of chemotherapy; testicular failure; sperm retrieval; congenital adrenal hyperplasia; microdissection testicular sperm extraction; testis histology
Journal Title: Fertility and Sterility
Volume: 102
Issue: 5
ISSN: 0015-0282
Publisher: Elsevier Science, Inc.  
Date Published: 2014-11-01
Start Page: 1282
End Page: 1286
Language: English
DOI: 10.1016/j.fertnstert.2014.08.007
PROVIDER: scopus
PUBMED: 25441063
PMCID: PMC4349348
Notes: Export Date: 2 March 2015 -- Source: Scopus
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