The outcomes of onco-testis sperm extraction at the time of radical orchiectomy Journal Article
| Authors: | Flores, J. M.; Henriquez, I.; Jue, J. S.; Benfante, N.; Sheinfeld, J.; Matulewicz, R. S.; Mulhall, J. P. |
| Article Title: | The outcomes of onco-testis sperm extraction at the time of radical orchiectomy |
| Abstract: | OBJECTIVE: To evaluate outcomes of onco-testis sperm extraction (TESE) and to define potential predictors of successful surgical sperm retrieval (SSR). METHODS: For this study, we examined all men (i) diagnosed with a testicular mass, (ii) who had azoospermia, and (iii) who underwent a radical orchiectomy and onco-TESE. Our institutional database of testicular cancer (TCA) patients was reviewed. Demographics, baseline endocrine and oncological characteristics, and treatments received were recorded. The onco-TESE Technique was performed at the time of radical orchiectomy before the specimen was sent for formal histopathological assessment. Onco-TESE was considered successful if viable sperm was found. Logistic regression assessments were performed to evaluate predictors of successful onco-TESE. RESULTS: Thirty-eight men with a median age of 35 were included in the analysis. Median baseline total testosterone, LH, and FSH levels were 419ng/dL, 10.9mU/mL, and 27mU/mL, respectively. The median pre-TESE testicular volume was 11 mL. Of men who underwent radical orchiectomy, 58% had unilateral tumors at the time of the procedure. 42% had bilateral tumors, which were synchronous in 25%, and asynchronous tumors in 75%. Pathologically, 76% had germ cell tumor (83% had pure seminoma, and 17% had mixed germ cell tumor). At onco-TESE, 24% of the patients had successful SSR. No variables had a statistically significant association with successful SSR. CONCLUSION: Onco-TESE represents a useful option for testis cancer patients who wish for future paternity, with a quarter of such patients having sperm found. Copyright © 2024 Elsevier Inc. All rights reserved. |
| Keywords: | adult; treatment outcome; middle aged; retrospective studies; young adult; pathology; retrospective study; testis tumor; testicular neoplasms; surgery; orchiectomy; etiology; azoospermia; complication; procedures; humans; human; male; sperm retrieval |
| Journal Title: | Urology |
| Volume: | 199 |
| ISSN: | 0090-4295 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2025-05-01 |
| Start Page: | 90 |
| End Page: | 94 |
| Language: | English |
| DOI: | 10.1016/j.urology.2024.12.005 |
| PUBMED: | 39674379 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding MSK author is Jose M. Flores -- Source: Scopus |
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