Clinical considerations in the management of individuals at risk for hereditary breast and ovarian cancer Journal Article
| Author: | Robson, M. E. |
| Article Title: | Clinical considerations in the management of individuals at risk for hereditary breast and ovarian cancer |
| Abstract: | Background: Hereditary predisposition to breast and ovarian cancer, most commonly due to germline mutations in BRCA1 and BRCA2, has been recognized for many years. The optimal clinical management of individuals with such a predisposition is not yet completely defined. Methods: The current literature regarding the clinical management of individuals at risk for hereditary breast and ovarian cancer was reviewed. Results: Women with germline BRCA1 or BRCA2 mutations are at substantially increased risk for breast and ovarian cancer, although the risks may not be as high as originally reported. Current surveillance options are restricted in their effectiveness by both host and tumor factors as well as limitations of the techniques. Surgical prevention options, while effective, may be complicated by physical or psychological morbidity. Nonsurgical prevention options are under development. Conclusions: The ability to define women as being at hereditary risk for breast and ovarian cancer facilitates the use of specialized surveillance and prevention strategies. Genetic testing, which plays a role in defining risk, requires careful pre- and post-test counseling to discuss the limitations of testing itself and available management strategies. |
| Keywords: | adult; aged; middle aged; unclassified drug; gene mutation; mutation; review; cancer risk; united states; salpingooophorectomy; genetic analysis; ovarian neoplasms; dna damage; dna repair; cancer susceptibility; genetic predisposition to disease; ovary cancer; breast cancer; prevalence; protein; health survey; breast neoplasms; brca1 protein; brca2 protein; protein p53; risk assessment; dna strand breakage; germ line; double stranded dna; genes, brca1; genes, brca2; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; atm protein; checkpoint kinase 2; familial cancer; ca 125 antigen; genetic screening; population surveillance; patient counseling; genetic linkage; transvaginal echography; protein kinase lkb1; humans; human; female |
| Journal Title: | Cancer Control |
| Volume: | 9 |
| Issue: | 6 |
| ISSN: | 1073-2748 |
| Publisher: | H. Lee Moffitt Cancer Center & Research Institute |
| Date Published: | 2002-11-01 |
| Start Page: | 457 |
| End Page: | 465 |
| Language: | English |
| PUBMED: | 12514563 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
