Considerations in genetic counseling for inherited breast cancer predisposition Journal Article
| Authors: | Robson, M. E.; Offit, K. |
| Article Title: | Considerations in genetic counseling for inherited breast cancer predisposition |
| Abstract: | Of the 190,000 women estimated to have been diagnosed with breast cancer in 2001, between 5% and 10% of them are likely to have developed their disease as the result of an inherited susceptibility. Although breast cancer is a component tumor of several familial cancer predisposition syndromes, mutations in BRCA1 and BRCA2 are the most commonly identified germline changes. Recognition of hereditary breast cancer is critical to allow the implementation of appropriate treatment, screening, and prevention strategies for the affected woman and her family members. Genetic testing may play an important role in refining risk assessment, identifying individuals at risk before cancer has developed, and relieving anxiety in family members who have not inherited the predisposition. Copyright 2002, Elsevier Science (USA). All rights reserved. |
| Keywords: | major clinical study; mutation; review; cancer diagnosis; cancer incidence; cancer susceptibility; genetic predisposition to disease; cancer prevention; breast cancer; prevalence; risk factors; cancer screening; breast neoplasms; brca1 protein; brca2 protein; risk assessment; cancer genetics; germ line; genes, brca1; genes, brca2; genetic susceptibility; familial cancer; syndrome delineation; anxiety; disease predisposition; heterozygote detection; genetic counseling; inheritance; humans; human; female; priority journal |
| Journal Title: | Seminars in Radiation Oncology |
| Volume: | 12 |
| Issue: | 4 |
| ISSN: | 1053-4296 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2002-10-01 |
| Start Page: | 362 |
| End Page: | 370 |
| Language: | English |
| DOI: | 10.1053/srao.2002.35255 |
| PUBMED: | 12382194 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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