Risk-reducing salpingo-oophorectomy in patients with germline mutations in BRCA1 or BRCA2 Journal Article
| Authors: | Kauff, N. D.; Barakat, R. R. |
| Article Title: | Risk-reducing salpingo-oophorectomy in patients with germline mutations in BRCA1 or BRCA2 |
| Abstract: | Women with mutations in BRCA1 or BRCA2 are at tremendously increased lifetime risk of both breast and BRCA-associated gynecologic (ovarian, fallopian tube, and primary peritoneal) cancer. Because of limitations in the efficacy of available screening and chemopreventive approaches for women with a mutation in one of these genes, surgical risk reduction, particularly risk-reducing salpingo-oophorectomy (RRSO), has become an important component of the management options in hereditary breast-ovarian cancer syndrome. This article will review the rationale and efficacy of RRSO for prevention of breast and BRCA-associated gynecologic cancer. Surgical technique and methods of pathologic evaluation will be presented. Controversies regarding uterine preservation and post-RRSO hormone replacement therapy will be addressed. Considerations that may impact the appropriate timing of the procedure will be reviewed, and the potential role of RRSO in BRCA-negative hereditary breast cancer families will also be discussed. © 2007 by American Society of Clinical Oncology. |
| Keywords: | surgical technique; gene mutation; genetics; mutation; review; cancer risk; united states; methodology; hysterectomy; salpingooophorectomy; ovarian neoplasms; cancer prevention; ovary cancer; peritoneum cancer; breast cancer; ovariectomy; estrogen; breast neoplasms; brca1 protein; brca2 protein; risk; oncogene; tumor suppressor gene; instrumentation; screening; genes, brca1; genes, brca2; nucleotide sequence; breast tumor; ovary tumor; tamoxifen; dna mutational analysis; menopause; risk reduction; genetic predisposition; models, anatomic; gynecologic cancer; canada; germ-line mutation; hormone substitution; raloxifene; uterine tube; audiovisual equipment; progesterone |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 25 |
| Issue: | 20 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2007-07-10 |
| Start Page: | 2921 |
| End Page: | 2927 |
| Language: | English |
| DOI: | 10.1200/jco.2007.11.3449 |
| PUBMED: | 17617523 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 45" - "Export Date: 17 November 2011" - "CODEN: JCOND" - "Source: Scopus" |
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